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Synthesis and Anti-MAO Activity of Acylation Products of Annelated Thiophene-2-amine and N-(5,5-Dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide and Their Complexes with Cu(II), Zn(II), Ba(II), and Co(II)
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2022-12-13 , DOI: 10.1134/s1070363222110391
A. U. Isakhanyan , N. Z. Hakobyan , A. S. Grigoryan , K. G. Navoyan , G. V. Gasparyan , R. P. Mkhitaryan , G. A. Panosyan , A. A. Harutyunyan

Abstract

Acylation of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile and 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile with various acids chlorides in anhydrous dioxane furnished the corresponding amides. Coordination compounds were obtained by reacting copper(II) chloride, zinc(II), cobalt(II), and barium(II) acetates with N-(5,5-dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide. Anti-MAO activity of the synthesized compounds was studied.

更新日期:2022-12-14
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