<br>骨组织工程支架：多材料分层结构支架的功能,Advanced Healthcare Materials

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骨组织工程支架：多材料分层结构支架的功能
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-12-13 , DOI: 10.1002/adhm.202202766
Tejas M Koushik ₁ , Catherine M Miller ₂ , Elsa Antunes ₁

Affiliation

骨组织工程（BTE）是过去十年来人们感兴趣的话题，材料、加工技术和对骨愈合途径的理解的进步开辟了新的研究途径。BTE 支架在提供承重能力和与局部细胞外基质相互作用以促进骨愈合方面的双重责任是合成支架中的一个挑战。本文介绍了多材料和分层结构的使用和加工，以模拟天然骨组织的结构，以发挥生物活性和承重合成支架的作用。本文献综述的第一部分描述了骨愈合反应的生理学和骨修复不同阶段的相互作用。以下部分回顾了有关用于 BTE 支架的生物材料的可用文献，然后是一些多材料方法。下一节讨论了支架结构特征对骨骼愈合的影响以及支架结构中分层分布的必要性。最后，本综述的最后一部分重点介绍了 BTE 支架发展的新兴趋势，这些趋势可以激发新的组织工程策略并真正开发下一代合成支架。

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Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds

Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, and the understanding of bone healing pathways have opened new avenues of research. The dual responsibility of BTE scaffolds in providing load-bearing capability and interaction with the local extracellular matrix to promote bone healing is a challenge in synthetic scaffolds. This article describes the usage and processing of multi-materials and hierarchical structures to mimic the structure of natural bone tissues to function as bioactive and load-bearing synthetic scaffolds. The first part of this literature review describes the physiology of bone healing responses and the interactions at different stages of bone repair. The following section reviews the available literature on biomaterials used for BTE scaffolds followed by some multi-material approaches. The next section discusses the impact of the scaffold's structural features on bone healing and the necessity of a hierarchical distribution in the scaffold structure. Finally, the last section of this review highlights the emerging trends in BTE scaffold developments that can inspire new tissue engineering strategies and truly develop the next generation of synthetic scaffolds.

更新日期：2022-12-13

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