An AIE-Active Cyclometalated Iridium(III) Photosensitizer for Selective Discrimination, Imaging, and Synergistic Elimination of Gram-Positive Bacteria,ACS Materials Letters

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An AIE-Active Cyclometalated Iridium(III) Photosensitizer for Selective Discrimination, Imaging, and Synergistic Elimination of Gram-Positive Bacteria
ACS Materials Letters ( IF 9.6 ) Pub Date : 2022-12-12 , DOI: 10.1021/acsmaterialslett.2c00774
Li Xu _{1,

2} , Peipei Deng ₁ , Wenzhu Song ₁ , Mengling Liu ₁ , Mengru Wang ₁ , Yue Yu ₃ , Feng Wang ₃

Affiliation

A platform integrating selective discrimination, imaging, and synergistic elimination of Gram-positive bacteria is urgently needed to address the problem of bacterial infection, especially those resulting from Gram-positive bacteria,. Aggregation-induced emission materials (AIEgens) have shown great promise for antimicrobial applications. Herein, three positively charged AIE-active cyclometalated iridium photosensitizers (Ir1–3) were rationally designed and synthesized. Selective discrimination and imaging of Gram-positive bacteria among Gram-positive bacteria, Gram-negative bacteria, and fungi were achieved with Ir1–3. Among three AIE-active cyclometalated iridium photosensitizers, Ir1 had the best antibacterial activity owing to the monoaromatic substituent of phenanthroline imidazole ligand to the main ligand, eliminating Gram-positive bacteria through its inherent antibacterial mechanism and bacterial photodynamic inactivation. Furthermore, Ir1 altered Gram-positive bacterial gene expression and was successfully applied to S. aureus-infected wound treatment. Due to the interaction between lipoteichoic acids (LTA) and our iridium-based AIEgens, our AIEgen photosensitizers realized selective discrimination, imaging, and synergistic elimination of Gram-positive bacteria.

中文翻译：

一种 AIE 活性环金属化铱 (III) 光敏剂，用于革兰氏阳性菌的选择性识别、成像和协同消除

迫切需要一个集成革兰氏阳性菌选择性鉴别、成像和协同消除的平台来解决细菌感染问题，尤其是革兰氏阳性菌引起的感染问题。聚集诱导发光材料 (AIEgens) 已显示出抗菌应用的巨大前景。在此，合理设计并合成了三种带正电荷的 AIE 活性环金属化铱光敏剂 ( Ir1-3 )。用Ir1-3实现了革兰氏阳性菌、革兰氏阴性菌和真菌中革兰氏阳性菌的选择性区分和成像。在三种 AIE 活性环金属化铱光敏剂中，Ir1由于菲咯啉咪唑配体对主要配体的单芳族取代基具有最佳的抗菌活性，通过其固有的抗菌机制和细菌光动力灭活作用消除了革兰氏阳性菌。此外，Ir1改变了革兰氏阳性细菌的基因表达，并成功应用于金黄色葡萄球菌感染的伤口治疗。由于脂磷壁酸 (LTA) 与我们基于铱的 AIEgen 之间的相互作用，我们的 AIEgen 光敏剂实现了对革兰氏阳性菌的选择性辨别、成像和协同消除。

更新日期：2022-12-12

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