A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins (2–6) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F (3) was the most active with an IC₅₀ value of 0.39 µM against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that 3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.

从泰国采集的酸浆全草的甲醇提取物中分离出一种新的1,2-二酮酸浆素、酸浆素XII( 1 )和13种已知化合物。其中， 5种酸浆蛋白( 2-6 )具有肿瘤坏死因子相关凋亡诱导配体(TRAIL)抵抗克服活性，其中酸浆蛋白F( 3 )的活性最强，对人胃腺癌的IC ₅₀值为0.39μM细胞系 AGS 在 TRAIL (100 ng/mL) 存在下。使用蛋白质印迹分析对 physalins 克服 TRAIL 抗性活性的研究表明， 3通过抑制抗凋亡蛋白 c-FLIP 和 Bcl-2 来促进 TRAIL 诱导的细胞凋亡。