聚合物基材上的“自我防御”防污两性离子水凝胶涂层,ACS Applied Materials & Interfaces

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聚合物基材上的“自我防御”防污两性离子水凝胶涂层
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-12-09 , DOI: 10.1021/acsami.2c17272
Jing Zhang ₁ , Minmin Wu ₁ , Pai Peng ₁ , Jiaqi Liu ₁ , Jie Lu ₁ , Sunxiang Qian ₁ , Jie Feng ₁

Affiliation

在生物医学领域，传感器、导管等设备很容易发生生物污染，引起一些医源性感染，极大地威胁着患者的生命和健康。因此，解决医疗器械表面细菌感染问题具有重要意义。在本文中，通过水凝胶和聚合物基材的网络互穿制备了“自我防御”和防污两性离子水凝胶涂层。两性离子聚磺基甜菜碱甲基丙烯酸酯 (PSBMA) 水凝胶涂层可抵抗大多数细菌粘附在基材上。当少数细菌幸运地逃脱防污防御并附着在涂层上时，硫酸庆大霉素（GS）会在细菌代谢产生的弱酸性环境的触发下释放出来杀死这些细菌。同时，细菌附着部位的涂层会被这些细菌分泌的透明质酸酶降解并剥离，以去除细菌并更新防污表面。研究了聚合物基材上水凝胶涂层的防污性能和自我防御行为机制。此外，证明了涂层的体外和体内抗菌性能以及生物相容性。结果表明，自防御防污两性离子水凝胶涂层在聚合物医疗器械表面具有巨大的应用潜力。

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“Self-Defensive” Antifouling Zwitterionic Hydrogel Coatings on Polymeric Substrates

In biomedicine fields, biofouling can easily occur on devices such as sensors and catheters, causing some iatrogenic infections, which menace the lives and health of patients greatly. Therefore, it is of great significance to solve the problems of bacterial infection on the surfaces of medical devices. In this paper, “self-defensive” and antifouling zwitterionic hydrogel coatings were prepared by network interpenetration of the hydrogel and the polymeric substrates. The zwitterionic polysulfobetaine methacrylate (PSBMA) hydrogel coatings resisted most of the bacteria to adhere on the substrates. When a few bacteria were lucky to escape the antifouling defense and adhered to the coatings, gentamicin sulfate (GS) would be released under the trigger of a weakly acidic environment caused by bacterial metabolism to kill these bacteria. Simultaneously, the coatings of the bacteria-adhering sites would be degraded by hyaluronidase secreted by these bacteria and peeled off to remove the bacteria and renew the antifouling surfaces. The antifouling properties and mechanism of the self-defensive behavior of the hydrogel coatings on polymeric substrates were investigated. Furthermore, the in vitro and in vivo antibacterial performances, as well as the biocompatibility of the coatings, were demonstrated. The results suggested that the self-defensive antifouling zwitterionic hydrogel coatings hold great potential to be used on the surfaces of polymeric medical devices.

更新日期：2022-12-09

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