调节蛋白质二级结构可实现具有可调机械性能的多功能水凝胶,Chemistry of Materials

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调节蛋白质二级结构可实现具有可调机械性能的多功能水凝胶
Chemistry of Materials ( IF 7.2 ) Pub Date : 2022-12-07 , DOI: 10.1021/acs.chemmater.2c02791
Zengkai Wang ₁ , Xiaolu Song ₁ , Xiangming Li ₁ , Xiaoyang Yue ₁ , Shuai Hou ₁ , Lei Liu ₁

Affiliation

调节材料的机械性能，尤其是蛋白质水凝胶，原位从弹性到塑性，反之亦然，这将是困难的，但由于有前景的应用的多样性而备受期待。在此，我们提出了一种制备具有可调机械性能的多功能水凝胶的策略。结果表明，我们可以在 60 秒内通过甲基丙烯酸缩水甘油酯 (RSF-MA) 和甲基丙烯酸酐 (Gel-MA) 对明胶进行化学改性，在 60 秒内快速制备再生丝素蛋白/明胶 (RSF/Gel) 共聚物水凝胶。此外，RSF/Gel 水凝胶通过控制 SF 的 β-折叠含量显示出可调的机械性能，可以实现原位弹性和塑性之间的可逆转换. 从弹性水凝胶到塑性水凝胶分别提高了 720 倍和 2000 倍，从而实现了断裂拉伸应力和 10% 应变下拉伸弹性模量的显着变化。塑料水凝胶在 50% 应变下的压缩弹性模量提高到 3.6 MPa，是弹性水凝胶的 62 倍。此外，RSF/Gel 水凝胶微针的药物释放性能可以通过控制 SF 的 β-折叠含量来调节，SF 可以作为药物载体，也可以作为其他有前途的生物材料用于各种生物学和临床应用。

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Regulating Protein Secondary Structures Enables Versatile Hydrogels with Tunable Mechanical Properties

Regulating the mechanical performance of a material, especially for protein hydrogels, in situ from elasticity to plasticity and vice versa would be difficult but highly anticipated due to the diversity of promising applications. Herein, we proposed a strategy to prepare versatile hydrogels with tunable mechanical properties. It was demonstrated that we could rapidly prepare regenerated silk fibroin/gelatin (RSF/Gel) copolymer hydrogels by chemically modifying RSF by glycidyl methacrylate (RSF-MA) and gelatin by methacrylic anhydride (Gel-MA) under UV light in 60 s. Furthermore, the RSF/Gel hydrogels showed tunable mechanical properties by controlling the β-sheet content of SF, which can realize reversible switch between elasticity and plasticity in situ. The significant alteration of tensile stress at break and tensile elastic modulus at 10% strain was achieved with 720 times and 2000 times improvement from an elastic to plastic hydrogel. The compressive elastic modulus at 50% strain of a plastic hydrogel was improved to 3.6 MPa, which was 62 times higher than that of an elastic hydrogel. In addition, the performance of drug release of RSF/Gel hydrogel microneedles could be modulated by controlling the β-sheet content of SF, which could be a drug carrier and also be other promising biomaterials for a variety of biological and clinical applications.

更新日期：2022-12-07

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