sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay,Angewandte Chemie International Edition

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sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-12-07 , DOI: 10.1002/anie.202215556
Xue Zhao ₁ , Jiaqi Liang ₁ , Ziye Chen , Ruijun Jian ₁ , Yao Qian ₂ , Yunfang Wang ₃ , Zhiying Guo ₃ , Wenpeng Zhang ₂ , Ying Zhang ₄ , Hang Yin ₄ , Yu Xia ₁

Affiliation

An isomer-resolving mass spectrometry assay reveals that lysophosphatidylcholine acyltransferase-1 (LPCAT1) has an sn-1 specificity when catalyzing the synthesis of phosphatidylcholines (PCs). The specific link between PC 18 : 1/16:0 and the activity of LPCAT1 enables visualization of the boundaries between cancerous and normal regions in human hepatocellular carcinoma (HCC) tissue via desorption electrospray ionization (DESI).

中文翻译：

溶血磷脂酰胆碱酰基转移酶 1 的 sn-1 特异性通过基于质谱的分析揭示

异构体分辨质谱分析表明，溶血磷脂酰胆碱酰基转移酶-1 (LPCAT1)在催化磷脂酰胆碱 (PC) 的合成时具有sn -1 特异性。PC 18 : 1/16:0 和 LPCAT1 活性之间的特定联系使得能够通过解吸电喷雾电离 (DESI) 可视化人肝细胞癌 (HCC) 组织中癌变区域和正常区域之间的边界。

更新日期：2022-12-07

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