Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry,Chemical Reviews

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Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry
Chemical Reviews ( IF 51.4 ) Pub Date : 2016-09-15 00:00:00 , DOI: 10.1021/acs.chemrev.6b00274
James A. Bull ₁ , Rosemary A. Croft ₁ , Owen A. Davis ₁ , Robert Doran ₁ , Kate F. Morgan ₁

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The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic intermediate. These applications have driven numerous studies into the synthesis of new oxetane derivatives. This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015. These methods are clustered by strategies for preparation of the ring and further derivatization of preformed oxetane-containing building blocks. Examples of the use of oxetanes in medicinal chemistry are reported, including a collation of oxetane derivatives appearing in recent patents for medicinal chemistry applications. Finally, examples of oxetane derivatives in ring-opening and ring-expansion reactions are described.

中文翻译：

氧杂环丁烷：合成，反应性和药物化学的最新进展。

四元氧杂环丁烷环因其相反的行为而得到了越来越多的开发：它对作为药物化学中稳定基序的理化性质的影响以及作为合成中间体发生开环反应的倾向。这些应用推动了对新的氧杂环丁烷衍生物的合成的大量研究。这篇综述对合成氧杂环丁烷衍生物的文献进行了概述，重点介绍了截至2015年底的过去五年中的进展。这些方法以环的制备策略和预制的含氧杂环丁烷建筑物的进一步衍生化为基础块。报道了氧杂环丁烷在药物化学中的使用实例，包括在药物化学应用的最新专利中出现的氧杂环丁烷衍生物的整理。最后，

更新日期：2016-09-15

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