Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones,Organic Letters

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Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones
Organic Letters ( IF 4.9 ) Pub Date : 2022-12-05 , DOI: 10.1021/acs.orglett.2c04017
Long Chen ₁ , Cong Shi ₁ , Wei Li ₁ , Bo Li ₁ , Jie Zhu ₁ , Aijun Lin ₁ , Hequan Yao ₁

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A palladium-catalyzed asymmetric C–C bond activation/carbonylation of cyclobutanones with CO has been developed. This reaction provided an efficient method for the synthesis of chiral indanones bearing a quaternary carbon stereocenter in good yields with an excellent enantiomeric ratio, exhibiting good functional group tolerance. Transformations of the products to chiral 3,4-dihydroquinolin-2(1H)-one and 1H-indene further demonstrated the versatility of this reaction.

中文翻译：

钯催化的不对称 C-C 键活化/环丁酮的羰基化

已开发出钯催化的环丁酮与 CO 的不对称 C-C 键活化/羰基化反应。该反应为合成带有季碳立构中心的手性茚满酮提供了一种有效的方法，其产率高，对映体比例高，具有良好的官能团耐受性。将产物转化为手性 3,4-二氢喹啉-2(1 H )-酮和 1 H-茚进一步证明了该反应的多功能性。

更新日期：2022-12-05

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