Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset,Japanese Journal of Radiology

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Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset
Japanese Journal of Radiology ( IF 2.9 ) Pub Date : 2022-12-06 , DOI: 10.1007/s11604-022-01370-2
Hiroyuki Tatekawa ₁ , Shu Matsushita ₁ , Daiju Ueda _{1,

2} , Hirotaka Takita ₁ , Daisuke Horiuchi ₁ , Natsuko Atsukawa ₁ , Yuka Morishita ₁ , Taro Tsukamoto ₁ , Taro Shimono ₁ , Yukio Miki ₁

Affiliation

Purpose

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is intended to reflect the glymphatic function of the brain; however, head rotation may reduce reproducibility and reliability. This study aimed to evaluate whether reorientation of DTI data improves the reproducibility of the ALPS index using the OASIS-3 dataset.

Materials and methods

234 cognitively normal subjects from the OASIS-3 dataset were included. Original and reoriented ALPS indices were calculated using a technique that registered vector information of DTI to another space and created reoriented diffusivity maps. The F test was used to compare variances of the original and reoriented ALPS indices. Subsequently, subjects with head rotation around the z- (inferior-superior; n = 43) or x axis (right-left; n = 25) and matched subjects with neutral head position were selected for evaluation of intra- and inter-rater reliability. Intraclass correlation coefficients (ICCs) of the original and reoriented ALPS indices for participants with head rotation and neutral head position were calculated separately. The Bland–Altman plot comparing the original and reoriented ALPS indices was also evaluated.

Results

The reoriented ALPS index exhibited a significantly smaller variance than the original ALPS index (p < 0.001). For intra- and inter-reliability, the reorientation technique showed good-to-excellent reproducibility in calculating the ALPS index even in subjects with head rotation (ICCs of original ALPS index: 0.52–0.81; ICCs of reoriented ALPS index: > 0.85). A wider range of the 95% limit of agreement of the Bland–Altman plot for subjects with x axis rotation was identified, indicating that x axis rotation may remarkably affect calculation of the ALPS index.

Conclusion

The technique used in this study enabled the creation of reoriented diffusivity maps and improved reproducibility in calculating the ALPS index.

中文翻译：

提高沿血管周围空间 (DTI-ALPS) 指数的扩散张量图像分析的再现性：OASIS-3 数据集重定向技术的分析

目的

沿血管周围空间（DTI-ALPS）指数的扩散张量图像分析旨在反映大脑的类淋巴功能；然而，头部旋转可能会降低再现性和可靠性。本研究旨在评估使用 OASIS-3 数据集重新定位 DTI 数据是否可以提高 ALPS 指数的可重复性。

材料和方法

OASIS-3 数据集中的 234 名认知正常受试者被纳入其中。原始和重新定向的 ALPS 指数是使用将 DTI 的矢量信息注册到另一个空间并创建重新定向的扩散率图的技术来计算的。F检验用于比较原始 ALPS 指数和重新定向的 ALPS 指数的方差。随后，选择头部绕z轴（下-上；n = 43）或x轴（右-左；n = 25）旋转的受试者和具有中立头部位置的匹配受试者来评估评估者内和评估者间的可靠性。分别计算头部旋转和中性头部位置的参与者的原始和重新定向的 ALPS 指数的组内相关系数 (ICC)。还评估了比较原始和重新定向的 ALPS 指数的 Bland-Altman 图。

结果

重新定向的 ALPS 指数表现出比原始 ALPS 指数显着更小的方差 ( p < 0.001)。对于内部和相互之间的可靠性，即使在头部旋转的受试者中，重新定向技术在计算 ALPS 指数时也显示出良好至极好的重现性（原始 ALPS 指数的 ICC：0.52–0.81；重新定向的 ALPS 指数的 ICC：> 0.85）。对于x轴旋转的受试者，确定了Bland-Altman 图的 95% 一致性极限范围更广，表明x轴旋转可能显着影响 ALPS 指数的计算。