Structurally Dynamic Gelatin-Based Hydrogels with Self-Healing, Shape Memory, and Cytocompatible Properties for 4D Printing,Biomacromolecules

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Structurally Dynamic Gelatin-Based Hydrogels with Self-Healing, Shape Memory, and Cytocompatible Properties for 4D Printing
Biomacromolecules ( IF 5.5 ) Pub Date : 2022-12-03 , DOI: 10.1021/acs.biomac.2c00924
Ziyan Wang ₁ , Jieyu Gu ₁ , Difei Zhang ₁ , Yan Zhang ₁ , Jinghua Chen ₁

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Three-dimensional (3D) printable hydrogels with a shape memory effect have emerged as a new class of 4D printing materials recently and found wide applications in various fields. However, synergistically endowing such materials with good mechanical strength and biocompatibility for biomedical uses remains challenging. In this study, a series of multiresponsive hydrogels have been prepared through a dynamic covalent imine/Diels–Alder network from biocompatible starting materials of modified gelatin and poly(ethylene glycol)-based polymers. By further secondary crosslinking with a hyperbranched triethoxysilane reagent (HPASi) that contains multiple supramolecular hydrogen bonding, the hydrogels presented a strengthened self-healing and temperature-responsive shape memory effect. With the additional features of superior stretchability (elongation at break up to 523%), good cytocompatibility, and 3D printable properties, these multifunctional hydrogels showed great potential for broad biomedical applications.

中文翻译：

用于 4D 打印的具有自我修复、形状记忆和细胞相容性的结构动态明胶基水凝胶

具有形状记忆效应的三维 (3D) 可打印水凝胶最近作为一类新型 4D 打印材料出现，并在各个领域得到广泛应用。然而，协同赋予此类材料良好的机械强度和生物相容性以用于生物医学用途仍然具有挑战性。在这项研究中，通过动态共价亚胺/Diels-Alder 网络从改性明胶和聚（乙二醇）基聚合物的生物相容性起始材料制备了一系列多响应水凝胶。通过与含有多个超分子氢键的超支化三乙氧基硅烷试剂 (HPASi) 进一步二次交联，水凝胶呈现出增强的自愈和温度响应形状记忆效应。

更新日期：2022-12-03

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