糖尿病后伤口愈合不良仍然是一个具有挑战性的问题,其病理生理机制尚未完全阐明。持续出血、炎症调节紊乱、细胞增殖受阻、易感感染和组织重塑受损是糖尿病伤口愈合的主要特征。传统的伤口敷料,包括纱布、薄膜和绷带,功能有限。它们通常作为渗出物的物理屏障和吸收剂,不能满足整个糖尿病创面愈合过程的要求。糖尿病患者的伤口通常愈合缓慢,并且由于伤口床内的高血糖而容易感染。一旦细菌细胞发展成生物膜,糖尿病伤口就会表现出强大的耐药性。最近,刺激响应水凝胶的应用,又被称为“智能水凝胶”,对于糖尿病创面的愈合尤为关注。该系统的基本特征是能够改变生物活性分子的机械性能、溶胀能力、亲水性、渗透性等,以响应各种刺激,包括温度、氢电位(pH)、蛋白酶和其他生物因素。智能水凝胶可以根据糖尿病伤口的特点提高治疗效果并限制总毒性。在这篇综述中,我们总结了刺激响应水凝胶在糖尿病伤口愈合中的作用机制和应用。希望本文的工作能为该领域的研究提供一些启发和建议。该系统的基本特征是能够改变生物活性分子的机械性能、溶胀能力、亲水性、渗透性等,以响应各种刺激,包括温度、氢电位(pH)、蛋白酶和其他生物因素。智能水凝胶可以根据糖尿病伤口的特点提高治疗效果并限制总毒性。在这篇综述中,我们总结了刺激响应水凝胶在糖尿病伤口愈合中的作用机制和应用。希望本文的工作能为该领域的研究提供一些启发和建议。该系统的基本特征是能够改变生物活性分子的力学性能、溶胀能力、亲水性、渗透性等,以响应各种刺激,包括温度、氢电位(pH)、蛋白酶和其他生物因素。智能水凝胶可以根据糖尿病伤口的特点提高治疗效果并限制总毒性。在这篇综述中,我们总结了刺激响应水凝胶在糖尿病伤口愈合中的作用机制和应用。希望本文的工作能为该领域的研究提供一些启发和建议。氢电位(pH)、蛋白酶和其他生物因素。智能水凝胶可以根据糖尿病伤口的特点提高治疗效果并限制总毒性。在这篇综述中,我们总结了刺激响应水凝胶在糖尿病伤口愈合中的作用机制和应用。希望本文的工作能为该领域的研究提供一些启发和建议。氢电位(pH)、蛋白酶和其他生物因素。智能水凝胶可以根据糖尿病伤口的特点提高治疗效果并限制总毒性。在这篇综述中,我们总结了刺激响应水凝胶在糖尿病伤口愈合中的作用机制和应用。希望本文的工作能为该领域的研究提供一些启发和建议。
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Recent advances in responsive hydrogels for diabetic wound healing
Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection and impaired tissue remodeling are the main features of diabetic wound healing. Conventional wound dressings, including gauze, films and bandages, have a limited function. They generally act as physical barriers and absorbers of exudates, which fail to meet the requirements of the whol diabetic wound healing process. Wounds in diabetic patients typically heal slowly and are susceptible to infection due to hyperglycemia within the wound bed. Once bacterial cells develop into biofilms, diabetic wounds will exhibit robust drug resistance. Recently, the application of stimuli-responsive hydrogels, also known as “smart hydrogels”, for diabetic wound healing has attracted particular attention. The basic feature of this system is its capacities to change mechanical properties, swelling ability, hydrophilicity, permeability of biologically active molecules, etc., in response to various stimuli, including temperature, potential of hydrogen (pH), protease and other biological factors. Smart hydrogels can improve therapeutic efficacy and limit total toxicity according to the characteristics of diabetic wounds. In this review, we summarized the mechanism and application of stimuli-responsive hydrogels for diabetic wound healing. It is hoped that this work will provide some inspiration and suggestions for research in this field.