Asymmetric functionalization of amines and their derivatives is of great significance in synthetic chemistry and is widely used in the preparation of natural products and pharmaceuticals. In recent years, chiral aldehyde catalysis has emerged as a well-established and recognized tool, providing excellent catalytic activation and stereoselective control in asymmetric reactions of N-unprotected amino acid esters and amino acid ester analogues. In this short review, recent advances in enantioselective aldehyde catalysis, including chiral aldehydes as organocatalysts and co-catalysis combined with transition metals, will be summarized. Lastly, continued development of enantioselective aldehyde catalysis is prospected in the future.

1 Introduction

2 Chiral Aldehyde Catalysis for Tethering Strategy

3 Chiral Aldehyde Catalysis for Imine Activation

4 Chiral Aldehyde/Transition Metal Cooperative Catalysis

5 Conclusion

胺及其衍生物的不对称功能化在合成化学中具有重要意义，广泛用于天然产物和药物的制备。近年来，手性醛催化已成为一种公认的工具，在 N-未保护的氨基酸酯和氨基酸酯类似物的不对称反应中提供出色的催化活化和立体选择性控制。在这篇简短的综述中，将总结对映选择性醛催化的最新进展，包括手性醛作为有机催化剂和与过渡金属结合的助催化。最后，展望未来对映选择性醛催化的持续发展。

1 简介

2 用于束缚策略的手性醛催化

3 手性醛催化亚胺活化

4 手性醛/过渡金属协同催化

5 结论