Synthesis ( IF 2.2 ) Pub Date : 2022-11-30 , DOI: 10.1055/a-1976-4931 Rakhi Katla 1 , Ramesh Katla 2 , Nelson Luís Campos Domingues 3
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Buchwald precatalyst (XantPhos Pd-G3) was employed for the first time in a C–S cross-coupling reaction involving 2-(4-bromophenyl)benzothiazole or 5-bromo-2,1,3-benzothiadiazole with various benzenethiols in DMF, K2CO3 as a base, under microwave irradiation at 80 °C, 200 W. Good to excellent yields of the desired products were obtained under microwave conditions. Other significant benefits of this synthetic approach are low catalyst loading, short reaction times, and eco-friendly conditions. Additionally, 29 compounds were successfully synthesized, some of which are new in this protocol.
中文翻译：
XantPhos Pd-G3 作为高效催化剂：DMF 中的微波辅助 C-S 交叉偶联反应
Buchwald 预催化剂 (XantPhos Pd-G3) 首次用于 2-(4-溴苯基) 苯并噻唑或 5-溴-2,1,3-苯并噻二唑与各种苯硫醇在 DMF 中的 C-S 交叉偶联反应， K 2 CO 3为碱，在80℃、200W的微波辐射下。在微波条件下获得了良好至优异收率的所需产物。这种合成方法的其他显着优点是催化剂负载低、反应时间短和环境友好的条件。此外，还成功合成了 29 种化合物，其中一些是本协议中的新化合物。
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