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Laser Ablation Secondary Electrospray Ionization for In Situ Mass Spectrometric Interrogation of Acoustically-Levitated Droplets
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-11-30 , DOI: 10.1021/acs.analchem.2c03800 Sebastian van Wasen 1 , Yi You 2 , Sebastian Beck 1 , Jens Riedel 2 , Dietrich A Volmer 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-11-30 , DOI: 10.1021/acs.analchem.2c03800 Sebastian van Wasen 1 , Yi You 2 , Sebastian Beck 1 , Jens Riedel 2 , Dietrich A Volmer 1
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The composition of acoustically levitated droplets was probed by a novel combination of mid-IR laser evaporation and subsequent postionization via secondary electrospray ionization. The combination of microliter samples and subnanoliter sampling provided time-resolved interrogation of droplets and allowed for a kinetic investigation of the laser-induced release of the analyte, which was found to strongly depend on the analytes. The observed substance-specific delayed release of the analytes permitted baseline-separated discrimination of the analytes, ideal for the study of complex samples. The additionally applied postionization scheme was found to enable efficient detection of small volatile compounds as well as peptides. The detection of small molecules and peptides occurred under very different sampling geometries, pointing to two distinct underlying ionization mechanisms. Overall, our results suggest that the experimental setup presented in this study can serve as a widely applicable platform to study chemical reactions in acoustically levitated droplets as model reactors.
中文翻译：
激光烧蚀二次电喷雾电离声悬浮液滴的原位质谱审讯
通过中红外激光蒸发和随后通过二次电喷雾电离进行定位的新型组合，探测了声学悬浮液滴的组成。微升样品和亚纳升样品的组合提供了对液滴的时间分辨询问，并允许对激光诱导的分析物释放进行动力学研究，发现这在很大程度上取决于分析物。观察到的分析物特定物质延迟释放允许对分析物进行基线分离区分，非常适合复杂样品的研究。发现另外应用的定位方案能够有效检测小的挥发性化合物和肽。小分子和肽的检测发生在非常不同的采样几何条件下，指向两个不同的潜在电离机制。总的来说，我们的结果表明，本研究中提出的实验装置可以作为一个广泛适用的平台来研究声学悬浮液滴中的化学反应作为模型反应器。
更新日期：2022-11-30
中文翻译：
激光烧蚀二次电喷雾电离声悬浮液滴的原位质谱审讯
通过中红外激光蒸发和随后通过二次电喷雾电离进行定位的新型组合，探测了声学悬浮液滴的组成。微升样品和亚纳升样品的组合提供了对液滴的时间分辨询问，并允许对激光诱导的分析物释放进行动力学研究，发现这在很大程度上取决于分析物。观察到的分析物特定物质延迟释放允许对分析物进行基线分离区分，非常适合复杂样品的研究。发现另外应用的定位方案能够有效检测小的挥发性化合物和肽。小分子和肽的检测发生在非常不同的采样几何条件下，指向两个不同的潜在电离机制。总的来说，我们的结果表明，本研究中提出的实验装置可以作为一个广泛适用的平台来研究声学悬浮液滴中的化学反应作为模型反应器。
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