The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection,Angewandte Chemie International Edition

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The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-30 , DOI: 10.1002/anie.202215916
Teresa Antón-Cánovas ₁ , Francisco Alonso ₁

Affiliation

We report the unprecedented use of the Eschemoser's salt—a well-known and commercial reagent for (dimethylamino)methylation reactions—as a formylation agent of indolizines. The method is simple and mild, whereas the classical formylation methods failed. Moreover, some indolizinecarbaldehydes have been transformed into highly conjugated push-pull dyes and have proven to be selective and sensitive colorimetric anion sensors for nitrite detection.

中文翻译：

Eschenmoser 盐作为甲酰化剂用于合成吲嗪甲醛及其在比色法检测亚硝酸盐中的应用

我们报道了 Eschemoser 盐（一种用于（二甲氨基）甲基化反应的众所周知的商业试剂）作为中氮茚甲酰化剂的前所未有的使用。该方法简单、温和，而经典的甲酰化方法则失败了。此外，一些中氮茚甲醛已转化为高度共轭的推拉染料，并已被证明是用于亚硝酸盐检测的选择性和灵敏的比色阴离子传感器。

更新日期：2022-11-30

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