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Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-11-30 , DOI: 10.1039/d2tb01826h Xuyue Liang 1 , Yang Lei 1 , Kailei Ding 1 , Xueyu Huang 1 , Cheng Zheng 1 , Yunbing Wang 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-11-30 , DOI: 10.1039/d2tb01826h Xuyue Liang 1 , Yang Lei 1 , Kailei Ding 1 , Xueyu Huang 1 , Cheng Zheng 1 , Yunbing Wang 1
Affiliation
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Commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated from the pericardium have become the most popular choice for treating heart valve diseases. Nevertheless, thrombosis, inflammation and calcification might lead to structural valve degeneration (SVD), which limited the durability of BHVs. Herein, to improve the biocompatibility of BHVs, we fabricated a poly-(2-methoxyethyl acrylate) (PMEA) coated porcine pericardium (PMEA-PP) through grafting PMEA to the porcine pericardium (PP) that was pre-treated with Glut and methacrylated polylysine. PMEA coating mitigated the side effects caused by aldehyde residues. It was shown that the PMEA coating reduced cytotoxicity and inflammation reactions and improved endothelialization potential, and its hydrophilic surface improved the anti-thrombotic properties of PPs. And the PMEA coating significantly reduced the calcification of PPs. This strategy promoted the endothelialization potential and improve the anti-thrombosis and anti-calcification properties of BHVs, and is expected to overcome the defects of commercial BHVs.
中文翻译：
聚（2-甲氧基丙烯酸乙酯）涂层生物修复心脏瓣膜通过共聚增强抗凝、抗炎和抗钙化特性
由心包膜制成的商用戊二醛 (Glut) 交联生物人工心脏瓣膜 (BHV) 已成为治疗心脏瓣膜疾病的最流行选择。然而，血栓形成、炎症和钙化可能导致结构性瓣膜退化 (SVD)，这限制了 BHV 的耐用性。在此，为了提高 BHV 的生物相容性，我们通过将 PMEA 接枝到用 Glut 和甲基丙烯酸酯预处理的猪心包膜 (PP) 上，制备了聚 (2-甲氧基丙烯酸乙酯) (PMEA) 涂层猪心包膜 (PMEA-PP)聚赖氨酸。PMEA 涂层减轻了醛类残留物引起的副作用。结果表明，PMEA 涂层降低了细胞毒性和炎症反应并提高了内皮化潜力，其亲水表面提高了 PP 的抗血栓形成性能。并且 PMEA 涂层显着降低了 PP 的钙化。该策略促进了BHVs的内皮化潜能，提高了BHVs的抗血栓形成和抗钙化特性，有望克服商业BHVs的缺陷。
更新日期：2022-11-30
中文翻译：
聚（2-甲氧基丙烯酸乙酯）涂层生物修复心脏瓣膜通过共聚增强抗凝、抗炎和抗钙化特性
由心包膜制成的商用戊二醛 (Glut) 交联生物人工心脏瓣膜 (BHV) 已成为治疗心脏瓣膜疾病的最流行选择。然而，血栓形成、炎症和钙化可能导致结构性瓣膜退化 (SVD)，这限制了 BHV 的耐用性。在此，为了提高 BHV 的生物相容性，我们通过将 PMEA 接枝到用 Glut 和甲基丙烯酸酯预处理的猪心包膜 (PP) 上，制备了聚 (2-甲氧基丙烯酸乙酯) (PMEA) 涂层猪心包膜 (PMEA-PP)聚赖氨酸。PMEA 涂层减轻了醛类残留物引起的副作用。结果表明，PMEA 涂层降低了细胞毒性和炎症反应并提高了内皮化潜力，其亲水表面提高了 PP 的抗血栓形成性能。并且 PMEA 涂层显着降低了 PP 的钙化。该策略促进了BHVs的内皮化潜能，提高了BHVs的抗血栓形成和抗钙化特性，有望克服商业BHVs的缺陷。
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