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Synthesis, crystal structure and biological properties of a fluorophore-labelled mixed-ligand copper(II) complex incorporating N-hydroxynaphthalene-1,8-dicarboximide
Acta Crystallographica Section C ( IF 0.7 ) Pub Date : 2022-11-28 , DOI: 10.1107/s2053229622011147 Satish Shantaram Bhat 1 , Vitthal A Kawade 2 , Vidyanand K Revankar 1 , Vijay Kumbar 3 , Kishore Bhat 3
Acta Crystallographica Section C ( IF 0.7 ) Pub Date : 2022-11-28 , DOI: 10.1107/s2053229622011147 Satish Shantaram Bhat 1 , Vitthal A Kawade 2 , Vidyanand K Revankar 1 , Vijay Kumbar 3 , Kishore Bhat 3
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The mixed-ligand fluorophore-labelled copper(II) complex aqua[2,4-dioxo-3-azatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaen-3-olato-κ2O2,O3](1,10-phenanthroline-κ2N,N′)copper(II) nitrate, [Cu(C12H6NO3)(C12H8N2)(H2O)]NO3·CH3OH or [Cu(L)(phen)(H2O)]NO3·CH3OH (where phen is 1,10-phenanthroline and HL is N-hydroxynaphthalene-1,8-dicarboximide), (1), was synthesized and structurally characterized. The structure of (1) was confirmed by single-crystal X-ray structure determination. The complex crystallized in the triclinic space group P
. The geometry around the copper centre is distorted square pyramidal, with the apical position occupied by a water molecule. The complex is highly fluorescent in organic and aqueous solutions. It has good anticancer activity, with an IC50 value of 17 µM, which is almost five times greater than cisplatin (IC50 = 82 µM) under identical experimental conditions.
中文翻译：
掺有 N-羟基萘-1,8-二甲酰亚胺的荧光团标记混合配体铜 (II) 配合物的合成、晶体结构和生物学特性
混合配体荧光团标记的铜 (II) 络合物 aqua[2,4-dioxo-3-azataricyclo[7.3.1.0 5,13 ]trideca-1(12),5,7,9(13),10-pentaen -3-olato-κ 2 O 2 , O 3 ](1,10-phenanthroline-κ 2 N , N ′)硝酸铜(II), [Cu(C 12 H 6 NO 3 )(C 12 H 8 N 2 )(H 2 O)]NO 3 ·CH 3 OH 或 [Cu( L )(phen)(H 2 O)]NO 3 ·CH 3 OH（其中 phen 是 1,10-菲咯啉和 H L是N -hydroxynaphthalene-1,8-dicarboximide), ( 1 ), 被合成并进行了结构表征。( 1 )的结构通过单晶X射线结构测定来确认。配合物在三斜空间群P中结晶。铜中心周围的几何形状是扭曲的方形金字塔，顶端位置被水分子占据。该络合物在有机溶液和水溶液中具有很强的荧光性。它具有良好的抗癌活性，IC 50值为 17 µ M ，在相同实验条件下几乎是顺铂 (IC 50 = 82 µ M ) 的五倍。
更新日期：2022-11-28
. The geometry around the copper centre is distorted square pyramidal, with the apical position occupied by a water molecule. The complex is highly fluorescent in organic and aqueous solutions. It has good anticancer activity, with an IC50 value of 17 µM, which is almost five times greater than cisplatin (IC50 = 82 µM) under identical experimental conditions.
中文翻译：
掺有 N-羟基萘-1,8-二甲酰亚胺的荧光团标记混合配体铜 (II) 配合物的合成、晶体结构和生物学特性
混合配体荧光团标记的铜 (II) 络合物 aqua[2,4-dioxo-3-azataricyclo[7.3.1.0 5,13 ]trideca-1(12),5,7,9(13),10-pentaen -3-olato-κ 2 O 2 , O 3 ](1,10-phenanthroline-κ 2 N , N ′)硝酸铜(II), [Cu(C 12 H 6 NO 3 )(C 12 H 8 N 2 )(H 2 O)]NO 3 ·CH 3 OH 或 [Cu( L )(phen)(H 2 O)]NO 3 ·CH 3 OH（其中 phen 是 1,10-菲咯啉和 H L是N -hydroxynaphthalene-1,8-dicarboximide), ( 1 ), 被合成并进行了结构表征。( 1 )的结构通过单晶X射线结构测定来确认。配合物在三斜空间群P
中结晶。铜中心周围的几何形状是扭曲的方形金字塔，顶端位置被水分子占据。该络合物在有机溶液和水溶液中具有很强的荧光性。它具有良好的抗癌活性，IC 50值为 17 µ M ，在相同实验条件下几乎是顺铂 (IC 50 = 82 µ M ) 的五倍。
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