Searching for new probes for pH detection is useful for the diagnosis of related diseases. However, the fluorescent probes that can respond to pH value less than 4 or greater than 8 are scarce and multisteps are needed to synthesize such probes. Thus, exploration of simple pH fluorescent probes for strong acid or basic system is an urgent task. Herein, we report a commercially available compound 6-chloroimidazo [1,2-a]pyridine-2-carboxylic acid IP-YC as the pH probe (> 7) and its bioimaging in S. cerevisiae and HepG2 cells.

中文翻译：

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用于碱性条件的基于咪唑并[1,2-a]吡啶-8-羧酸的简单且可商购的荧光 pH 探针

寻找新的pH检测探针有助于相关疾病的诊断。然而，能够响应小于 4 或大于 8 的 pH 值的荧光探针很少，需要多步合成此类探针。因此，探索用于强酸或强碱体系的简单pH荧光探针是当务之急。在此，我们报告了一种市售化合物 6-chloroimidazo [1,2-a]pyridine-2-carboxylic acid IP-YC作为 pH 探针 (> 7) 及其在酿酒酵母和 HepG2 细胞中的生物成像。