具有延长循环和增强渗透的近红外光响应纳米系统，用于增加光热和光动力疗法,ACS Materials Letters

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具有延长循环和增强渗透的近红外光响应纳米系统，用于增加光热和光动力疗法
ACS Materials Letters ( IF 9.6 ) Pub Date : 2022-11-23 , DOI: 10.1021/acsmaterialslett.2c00707
Fangli Gao ₁ , Liting Jiang ₂ , Jie Zhang ₁ , Yi Chang ₁ , Weihua Gao ₁ , Lina Ding ₂ , Guanglei Ma ₂ , Xiaoming Ma ₂ , Yuming Guo ₁

Affiliation

通过克服渗透性差和同时增强纳米药物的积累来优化肿瘤治疗效果仍然是一个挑战。在这里，我们开发了一种近红外 (NIR) 光触发可分解递送系统 (Lipo @ ICG @CuS）由热敏脂质体、光敏剂吲哚菁绿（ICG）和超小硫化铜纳米颗粒（CuS NPs）组成，其中ICG嵌入脂质双层中，CuS NPs分别封装在脂质体的空腔中。在被 808 nm NIR 激光照射后，Lipo@ICG@CuS NPs 的局部温度显着升高，这是由于负载的 CuS NPs 的光热能力，随后导致热敏脂质体的结构崩溃以释放 ICG 和 CuS纳米粒子。体外和体内_结果表明，所制备的 Lipo@ICG@CuS NPs 可以显着促进 CuS NPs 在肿瘤中深入渗透和积累，并通过组合光动力疗法 (PDT) 和光热疗法 (PTT) 获得显着的抗肿瘤功效。本研究为解决纳米药物肿瘤治疗过程中大尺寸纳米粒子血液循环长但渗透积累差以及小尺寸纳米粒子穿透深易清除的固有困境提供了新的策略。

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Near-Infrared Light-Responsive Nanosystem with Prolonged Circulation and Enhanced Penetration for Increased Photothermal and Photodynamic Therapy

It is still a challenge to optimize the tumor therapeutic efficacy via overcoming poor penetration and enhancing accumulation of nanomedicines simultaneously. Here, we developed a near-infrared (NIR) light-triggered disintegratable delivery system (Lipo@ICG@CuS) composed of thermosensitive liposome, photosensitizer indocyanine green (ICG), and ultrasmall copper sulfide nanoparticles (CuS NPs), where ICG was embedded in the lipid bilayer and CuS NPs were encapsulated into the cavity of the liposome, respectively. Upon being irradiated by an 808 nm NIR laser, the local temperature of Lipo@ICG@CuS NPs is increased significantly, because of the photothermal capability of the loaded CuS NPs, and subsequently induces the structural collapse of thermosensitive liposomes to release the ICG and CuS NPs. The in vitro and in vivo results indicated that the as-prepared Lipo@ICG@CuS NPs could considerably prompt the CuS NPs to penetrate and accumulate deeply in tumors and obtained distinguished antitumor efficacy by combinatorial photodynamic therapy (PDT) and photothermal therapy (PTT). The current study provides a new strategy for solving the inherent dilemma of the long blood circulation but poor penetration and accumulation of large-sized NPs, as well as the deep penetration but easy clearance of small-sized NPs during the tumor therapy of nanomedicines.

更新日期：2022-11-23

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