Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography,Journal of Nuclear Cardiology

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Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
Journal of Nuclear Cardiology ( IF 3.0 ) Pub Date : 2024-01-04 , DOI: 10.1007/s12350-022-03142-x
K A Jones _{1,

2} , C A Paterson _{1,

2} , S Ray ₃ , D W Motherwell ₁ , D J Hamilton ₂ , A D Small _{1,

4} , W Martin _{1,

2} , N E R Goodfield ₁

Affiliation

Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.

中文翻译：

通过放射性核素心室造影评估心力衰竭中的β受体阻滞剂和机械不同步

放射性核素心室造影（RNVG）可用于量化机械不同步，并且可能是评估射血分数降低的心力衰竭（HFrEF）的有价值的辅助手段。该研究旨在利用新型 RNVG 相位参数研究 β 受体阻滞剂对机械不同步的影响。对 98 名 HFrEF 患者进行了一项回顾性研究。在β-阻断前后评估 LVEF 和不同步。使用平面 RNVG 相位图像的同步性、熵、相位标准差、近似熵和样本熵来评估不同步性。还研究了按缺血病因划分的亚组。 β-阻断后六个月，缺血组和非缺血组的不同步性和 LVEF 均得到改善。使用新的不同步测量方法测量β-阻断后不同步和 LVEF 的显着改善。

更新日期：2024-01-04

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