Simple and Commercially Available 6-chloroimidazo[1,2-a]pyridine-2-carboxylic Acid-based Fluorescent Probe for Monitoring pH Changes,Journal of Fluorescence

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Simple and Commercially Available 6-chloroimidazo[1,2-a]pyridine-2-carboxylic Acid-based Fluorescent Probe for Monitoring pH Changes
Journal of Fluorescence ( IF 2.6 ) Pub Date : 2022-11-21 , DOI: 10.1007/s10895-022-03086-y
Yunlong Gao ₁ , Guangle Song ₂ , Guowei Shi ₂ , Jixiang Xiao ₂ , Chunhao Yuan ₂ , Yanqing Ge ₂

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Commercially available compounds that can be directly used as fluorescent probes will greatly promote the development of fluorescent imaging. Based on our previously work related to nitrogen bridgehead heterocycles, herein, a commercially available compound, 6-chloroimidazo[1,2-a]pyridine-2-carboxylic acid, has been detected for monitoring pH value (3.0–7.0). The probe proves to have high selectivity and sensitivity, brilliant reversibility, and extremely short response time. The real-time imaging of pH changes in yeast was also conducted.

中文翻译：

用于监测 pH 变化的基于 6-chloroimidazo[1,2-a]pyridine-2-carboxylic 酸的简单且可商购的荧光探针

可直接用作荧光探针的市售化合物将极大地促进荧光成像的发展。基于我们之前与氮桥头杂环化合物相关的工作，本文检测了一种市售化合物 6-氯咪唑并[1,2-a] 吡啶-2-羧酸，用于监测 pH 值 (3.0–7.0)。该探针被证明具有高选择性和灵敏度、出色的可逆性和极短的响应时间。还进行了酵母 pH 变化的实时成像。

更新日期：2022-11-26

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