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Phototherapy and Mechanism Exploration of Biofilm and Multidrug-Resistant Helicobacter pylori by Bacteria-Targeted NIR Photosensitizer
Small ( IF 13.0 ) Pub Date : 2022-11-23 , DOI: 10.1002/smll.202205248 Yanqi Qiao 1 , Yan Ma 1 , Yue Tong 1 , Wenting Liu 1 , Shuo Wang 1 , Ying Zheng 2 , Changjun Men 3 , Jie Yu 4 , Jie Pan 5 , Dong Wan 5 , Yongmei Yin 1 , Xiujie Zhao 1 , Rimo Xi 1 , Meng Meng 1
Small ( IF 13.0 ) Pub Date : 2022-11-23 , DOI: 10.1002/smll.202205248 Yanqi Qiao 1 , Yan Ma 1 , Yue Tong 1 , Wenting Liu 1 , Shuo Wang 1 , Ying Zheng 2 , Changjun Men 3 , Jie Yu 4 , Jie Pan 5 , Dong Wan 5 , Yongmei Yin 1 , Xiujie Zhao 1 , Rimo Xi 1 , Meng Meng 1
Affiliation
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Helicobacter pylori (H. pylori) infection has been the leading cause of gastric cancer development. In recent years, the resistance of H. pylori against antibiotic treatment has been a great challenge for most countries worldwide. Since biofilm formation is one of the reasons for the antibiotic resistance of H. pylori, and phototherapy has emerged as a promisingly alternative antibacterial treatment, herein the bacteria-targeted near-infrared (NIR) photosensitizer (T780T-Gu) by combining positively-charged guanidinium (Gu) with an efficient phototherapeutic agent T780T is developed. The proposed molecule T780T-Gu exhibits synergistic photothermal therapy/photodynamic therapy effect against both H. pylori biofilms and multidrug-resistant (MDR) clinical strains. More importantly, the phototherapy mechanism of T780T-Gu acquired by the RNA-seq analysis indicates that structural deficiency as well as a decrease in metabolism and defense activity are the possible reasons for the efficient H. pylori phototherapy.
中文翻译：
细菌靶向 NIR 光敏剂对生物膜和多重耐药幽门螺杆菌的光疗和机制探索
幽门螺杆菌( H. pylori ) 感染一直是胃癌发展的主要原因。近年来，幽门螺杆菌对抗生素治疗的耐药性一直是全球大多数国家面临的巨大挑战。由于生物膜形成是幽门螺杆菌抗生素耐药性的原因之一，并且光疗已成为一种很有前途的替代抗菌治疗方法，本文将细菌靶向的近红外 (NIR) 光敏剂 (T780T-Gu) 通过结合带正电荷的开发了具有高效光疗剂 T780T 的胍 (Gu)。拟议的分子 T780T-Gu 对幽门螺杆菌表现出协同光热疗法/光动力疗法效果生物膜和多重耐药 (MDR) 临床菌株。更重要的是，通过RNA-seq分析获得的T780T-Gu的光疗机制表明结构缺陷以及代谢和防御活性的降低是H. pylori光疗有效的可能原因。
更新日期：2022-11-23
中文翻译：
细菌靶向 NIR 光敏剂对生物膜和多重耐药幽门螺杆菌的光疗和机制探索
幽门螺杆菌( H. pylori ) 感染一直是胃癌发展的主要原因。近年来，幽门螺杆菌对抗生素治疗的耐药性一直是全球大多数国家面临的巨大挑战。由于生物膜形成是幽门螺杆菌抗生素耐药性的原因之一，并且光疗已成为一种很有前途的替代抗菌治疗方法，本文将细菌靶向的近红外 (NIR) 光敏剂 (T780T-Gu) 通过结合带正电荷的开发了具有高效光疗剂 T780T 的胍 (Gu)。拟议的分子 T780T-Gu 对幽门螺杆菌表现出协同光热疗法/光动力疗法效果生物膜和多重耐药 (MDR) 临床菌株。更重要的是，通过RNA-seq分析获得的T780T-Gu的光疗机制表明结构缺陷以及代谢和防御活性的降低是H. pylori光疗有效的可能原因。
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