A donor-acceptor covalent organic framework (COF), TB-COF, constructed from an electron-rich building unit (donor) and an electron-deficient building unit (acceptor), was developed as a promising photothermal agent for photothermal therapy (PTT). Upon laser irradiation, significant photoinduced electron transfer (PET) occurs between the donor and acceptor in TB-COF, converting the absorbed optical energy to thermal energy and resulting in the ablation of tumor. TB-COF possessed satisfying photothermal conversion efficiency, reaching 43.65%, similar to materials commonly used for PTT. Moreover, hyaluronic acid (HA) was coated on TB-COF to improve its biocompatibility and achieve tumor targeting. Furthermore, in vitro and in vivo experiments confirmed satisfying photothermal anticancer efficacy of TB-COF-HA.

由富电子结构单元（供体）和缺电子结构单元（受体）构成的供体-受体共价有机骨架 (COF) TB-COF 被开发为用于光热疗法 (PTT) 的有前途的光热剂. 在激光照射下，TB-COF 中的供体和受体之间发生显着的光诱导电子转移 (PET)，将吸收的光能转化为热能，从而导致肿瘤消融。TB-COF具有令人满意的光热转换效率，达到43.65%，与常用的PTT材料相似。此外，透明质酸（HA）被包覆在TB-COF上以提高其生物相容性并实现肿瘤靶向。此外，体外和体内实验证实了TB-COF-HA令人满意的光热抗癌功效。