Effects of Fe3O4 Magnetic Nanoparticle Functionalization with Ionic Liquids and a Double-Chained Surfactant on the Pretreatment of Plasma Samples during Drug Extraction,Analytical Chemistry

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Effects of Fe3O4 Magnetic Nanoparticle Functionalization with Ionic Liquids and a Double-Chained Surfactant on the Pretreatment of Plasma Samples during Drug Extraction
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-11-22 , DOI: 10.1021/acs.analchem.2c01985
Natalia Treder ₁ , Anna Roszkowska ₂ , Ilona Olędzka ₂ , Tomasz Bączek ₂ , Alina Plenis ₁

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Ionic liquids (ILs), also known as “designer solvents,” comprise a large group of compounds that can improve overall sample preparation performance due to their unique physical and chemical properties. Some of them have a comparable structure to surfactants, which can be also considered as effective extraction solvents. In this study, nine different ILs and a double-chained surfactant were investigated as potential coating materials for iron oxide-based nanoparticles (NPs) used in the pretreatment of human plasma samples. Various methods of synthesizing and functionalizing NPs were employed in fabricating the magnetic sorbents, with the physicochemical properties of the resultant extraction phases (i.e., naked NPs, NPs coated with silica, and NPs coated with silica and selected IL or surfactant) being characterized via X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TG), and transmission electron microscopy (TEM). The effectiveness of the developed NP-based extraction phases was tested by applying them for the extraction of epirubicin hydrochloride (EPI) from plasma samples, followed by analysis via liquid chromatography with fluorescence detection (LC-FL). The results showed that NPs coated with both silica and IL or silica and surfactant provided significantly higher extraction efficiency compared to naked NPs and NPs coated solely with silica. Additionally, the findings also revealed that the adsorption of analytes depends not only on the coating procedure but also on the type of coating material used to functionalize the NPs. Among the tested structures, didodecyldimethylammonium bromide provided the best performance for the functionalization of NP sorbents previously coated with silica.

中文翻译：

离子液体和双链表面活性剂功能化 Fe3O4 磁性纳米粒子对药物提取过程中血浆样品预处理的影响

离子液体 (IL)，也称为“设计溶剂”，包含一大类化合物，由于其独特的物理和化学性质，它们可以提高整体样品制备性能。其中一些具有与表面活性剂相当的结构，也可以被认为是有效的萃取溶剂。在这项研究中，研究了九种不同的离子液体和一种双链表面活性剂作为用于预处理人体血浆样品的氧化铁基纳米粒子 (NPs) 的潜在涂层材料。在制造磁性吸附剂时采用了各种合成和功能化 NP 的方法，所得萃取相（即裸露 NP、二氧化硅包覆的 NP 以及二氧化硅和选定的 IL 或表面活性剂包覆的 NP）的物理化学性质通过 X 表征-射线衍射（XRD），傅里叶变换红外 (FT-IR) 光谱、热重分析 (TG) 和透射电子显微镜 (TEM)。通过将开发的基于 NP 的萃取相应用于从血浆样品中萃取表柔比星盐酸盐 (EPI)，然后通过带荧光检测的液相色谱 (LC-FL) 进行分析，测试了开发的基于 NP 的萃取相的有效性。结果表明，与裸 NP 和仅涂有二氧化硅的 NP 相比，同时涂有二氧化硅和 IL 或二氧化硅和表面活性剂的 NP 提供了显着更高的提取效率。此外，研究结果还表明，分析物的吸附不仅取决于涂层程序，还取决于用于使 NP 功能化的涂层材料的类型。在测试的结构中，

更新日期：2022-11-22

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