A chiral phosphoric acid-catalyzed ring-opening of meso-epoxides was developed. A range of 2-azabicyclo[2.2.1]heptanes were obtained in high yields with excellent enantioselectivities. In addition, the hydroxyl and amide groups in the products provided handles for further derivatization.

中文翻译：

---

2-氮杂双环 [2.2.1] 庚烷的对映选择性合成通过 Brønsted 酸催化内消旋环氧化物的开环

开发了手性磷酸催化的内消旋环氧化物开环。一系列 2-氮杂双环 [2.2.1] 庚烷以高产率和优异的对映选择性获得。此外，产物中的羟基和酰胺基团为进一步衍生化提供了把手。