The valorization of organosolv pretreatment (OP) is a required approach to the industrialization of the current enzyme-mediated lignocellulosic biorefinery. Recent literature has demonstrated that the solvolysis happening in the OP can modify the soluble components into value-added active compounds, namely organosolv modified lignin (OML) and organosolv modified sugars (OMSs), in addition to protecting them against excessive degradation. Among them, the OML is coincidental with the “lignin-first” strategy that should render a highly reactive lignin enriched with β-O-4 linkages and less condensed structure by organosolv grafting, which is desirable for the transformation into phenolic compounds. The OMSs are valuable glycosidic compounds mainly synthesized by trans-glycosylation, which can find potential applications in cosmetics, foods, and healthcare. Therefore, a state-of-the-art OP holds a big promise of lowering the process cost by the valorization of these active compounds. Recent advances in organosolv modified components are reviewed, and perspectives are made for addressing future challenges.

有机溶剂预处理 (OP) 的增值是当前酶介导的木质纤维素生物精炼工业化的必要方法。最近的文献表明，OP 中发生的溶剂分解可以将可溶性成分改性为增值活性化合物，即有机溶剂改性木质素 (OML) 和有机溶剂改性糖 (OMS)，此外还可以防止它们过度降解。其中，OML 与“木质素优先”策略不谋而合，该策略应提供富含β的高反应性木质素-O-4 键和通过有机溶剂接枝得到的缩合结构较少，这对于转化为酚类化合物是理想的。OMSs 是有价值的糖苷化合物，主要通过转糖基化作用合成，可在化妆品、食品和保健领域找到潜在的应用。因此，最先进的 OP 有望通过这些活性化合物的增值来降低工艺成本。回顾了有机溶剂改性组分的最新进展，并提出了应对未来挑战的观点。