BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self-Assembly, Properties, and Applications,Advanced Materials

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self-Assembly, Properties, and Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2022-11-18 , DOI: 10.1002/adma.202207546
Hong-Bo Cheng ₁ , Xiaoqiao Cao ₁ , Shuchun Zhang ₁ , Keyue Zhang ₁ , Yang Cheng ₁ , Jiaqi Wang ₁ , Jing Zhao ₁ , Liming Zhou ₂ , Xing-Jie Liang _{3,

4} , Juyoung Yoon ₅

Affiliation

The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, and inspiring cutting-edge work in post-functionalization strategies is highlighted. A brief overview of assembly model of BODIPY is then provided: BODIPY is introduced as a promising building block for the formation of single- and multicomponent self-assembled systems, including nanostructures suitable for aqueous environments, thereby showing the great development potential of supramolecular assembly in biomedicine applications. The frontier progress of BODIPY in biomedical application is thereafter described, supported by examples of the frontiers of biomedical applications of BODIPY-containing smart materials: it mainly involves the application of materials based on BODIPY building blocks and their assemblies in fluorescence bioimaging, photoacoustic imaging, disease treatment including photodynamic therapy, photothermal therapy, and immunotherapy. Lastly, not only the current status of the BODIPY family in the biomedical field but also the challenges worth considering are summarized. At the same time, insights into the future development prospects of biomedically applicable BODIPY are provided.

中文翻译：

BODIPY 作为生物医学中的多功能治疗诊断试剂：自组装、特性和应用

综述了二吡咯亚甲基硼 (BODIPY) 在生物医学中的应用。首先，总结了其综合和监管策略，并强调了后功能化策略中鼓舞人心的前沿工作。然后简要概述了 BODIPY 的组装模型：BODIPY 被介绍为一种有前途的构建模块，用于形成单组分和多组分自组装系统，包括适用于水性环境的纳米结构，从而显示了超分子组装在水性环境中的巨大发展潜力。生物医学应用。随后介绍了BODIPY在生物医学应用的前沿进展，并举例说明了含BODIPY的智能材料的生物医学应用前沿：主要涉及基于BODIPY构件及其组装体的材料在荧光生物成像、光声成像、疾病治疗包括光动力疗法、光热疗法和免疫疗法。最后，总结了BODIPY家族在生物医学领域的现状以及值得思考的挑战。同时，对生物医学适用的BODIPY未来的发展前景进行了展望。

更新日期：2022-11-18

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