OBJECTIVE To observe the clinical effect of acupuncture combined with Qingfei Qutan decoction for stroke-associated pneumonia (SAP) with phlegm-heat obstructing lung, and explore its possible mechanism. METHODS Ninety-nine patients of SAP with phlegm-heat obstructing lung were randomly divided into a combination group (33 cases, 1 case dropped off), a Chinese medication group (33 cases, 1 case dropped off) and an acupuncture group (33 cases, 1 case dropped off). On the basis of routine basic treatment, the patients in the acupuncture group were treated with acupuncture at Tiantu (CV 22), Feishu (BL 13), Taiyuan (LU 9), Sanyinjiao (SP 6), etc., once a day, with an interval of 1 day after continuous 6-day treatment; the patients in the Chinese medication group were treated with Qingfei Qutan decoction, 1 dose per day; the patients in the combination group were treated with acupuncture combined with Qingfei Qutan decoction. Two weeks were taken as a course of treatment, and two courses of treatment were given. Before and after treatment, the clinical pulmonary infection score (CPIS), inflammatory indexes (neutrophil-to-lymphocyte ratio [NLR], procalcitonin [PCT], C-reactive protein [CRP]), cellular immune function (CD+3, CD+4, CD+8 and CD+4/CD+8) were compared in the 3 groups. The clearance of pathogenic bacteria after treatment was observed in the 3 groups. The clinical efficacy of each group was evaluated. RESULTS After treatment, the CPIS scores, NLR, PCT, CRP and CD+8 in the each group were lower than those before treatment (P<0.05), while the levels of CD+3, CD+4, CD+4/CD+8 were higher than those before treatment (P<0.05). The above indexes in the combination group were better than those in the acupuncture group and the Chinese medication group (P<0.05), and the above indexes in the Chinese medication group were better than those in the acupuncture group (P<0.05). There was no significant difference in the clearance rate of pathogenic bacteria among three groups (P>0.05). The cured and markedly effective rate was 65.6% (21/32) in the combination group, which was higher than 43.8% (14/32) in the Chinese medication group and 18.8% (6/32) in the acupuncture group (P<0.05). The cured and markedly effective rate in the Chinese medication group was higher than that in the acupuncture group (P<0.05). CONCLUSION Acupuncture combined with Qingfei Qutan decoction could effectively improve the clinical symptoms of SAP patients with phlegm-heat obstructing lung, and the mechanism may be related to enhancing the cellular immune function and reducing the level of inflammatory reaction.

中文翻译：

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针刺联合清肺祛痰汤治疗中风并发肺炎痰热阻肺及对细胞免疫功能的影响[J].

目的观察针刺联合清肺祛痰汤治疗中风相关性肺炎(SAP)痰热阻肺的临床疗效，并探讨其可能的作用机制。方法将99例SAP合并痰热阻肺患者随机分为联合组（33例，脱落1例）、中药组（33例，脱落1例）和针刺组（33例）。 , 1 例脱落）。针刺组在常规基础治疗的基础上,针刺天突(CV 22)、肺俞(BL 13)、太原(LU 9)、三阴交(SP 6)等处,每日1次,连续治疗6天后间隔1天；中药组口服清肺祛痰汤，每日1剂。联合组患者采用针刺配合清肺祛痰汤治疗。以两周为一个疗程，分两个疗程。治疗前后临床肺部感染评分（CPIS）、炎症指标（中性粒细胞淋巴细胞比值[NLR]、降钙素原[PCT]、C反应蛋白[CRP]）、细胞免疫功能（CD+3、CD +4、CD+8和CD+4/CD+8)在3组中进行比较。观察3组治疗后病原菌清除情况。评价各组的临床疗效。结果 治疗后各组CPIS评分、NLR、PCT、CRP、CD+8均低于治疗前（P<0.05），CD+3、CD+4、CD+4/CD水平+8高于治疗前(P<0.05)。联合组上述指标优于针刺组和中药组（P<0.05），中药组上述指标优于针刺组（P<0.05）。三组间病原菌清除率差异无统计学意义（P>0.05）。联合组治愈显效率65.6%（21/32），高于中药组43.8%（14/32）和针刺组18.8%（6/32）（P< 0.05）。中药组治愈显效率高于针刺组(P<0.05)。结论针刺联合清肺祛痰汤可有效改善SAP患者痰热阻肺的临床症状,