用于封闭止血的多糖基粘合剂抗菌自愈水凝胶,Biomacromolecules

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用于封闭止血的多糖基粘合剂抗菌自愈水凝胶
Biomacromolecules ( IF 5.5 ) Pub Date : 2022-11-17 , DOI: 10.1021/acs.biomac.2c00943
Xiaoli Zhao ₁ , Ya-Feng Huang ₂ , Xuan Tian ₂ , Jinni Luo ₁ , Huanxia Wang ₁ , Jinfei Wang ₁ , Yuan Chen ₁ , Pengxiang Jia ₁

Affiliation

粘性水凝胶被认为是最理想的伤口敷料材料之一。然而，现有的大多数粘附性水凝胶仍存在机械性能低、生物活性（抗菌和止血能力）差、生物相容性低等缺点，在很大程度上限制了其应用。因此，迫切需要制备一种具有良好自愈性、理想的粘合性能、快速止血和优异的伤口感染预防活性的水凝胶伤口敷料。在这项研究中，提出了一种制备用于伤口敷料的 PAM-Lignin-CS-Laponite-SA 水凝胶的简单方法。得益于在水凝胶网络内部引入氢键和静电相互作用，所获得的水凝胶显示出优异的自愈能力和可重复的粘合性能。此外，PAM-Lignin-CS-Laponite-SA 水凝胶还表现出低细胞毒性、良好的抗菌活性和出色的止血性能。总之，PAM-Lignin-CS-Laponite-SA水凝胶表现出良好的组织粘附性、优异的自愈能力、有效的出血控制以及良好的抗菌活性以防止伤口感染，为开发基于多功能水凝胶提供了新思路。组织粘合剂止血敷料。

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Polysaccharide-Based Adhesive Antibacterial and Self-Healing Hydrogel for Sealing Hemostasis

Adhesive hydrogels have been considered as one of the most ideal materials for wound dressing. However, most existing adhesive hydrogels still have disadvantages such as low mechanical properties, poor biological activity (antibacterial and hemostatic ability), and low biocompatibility, which largely limit their application. Thus, it is highly desired to prepare a hydrogel-based wound dressing with good self-healing, ideal adhesive properties, rapid hemostasis, and excellent wound infection prevention activity. In this study, a simple method was presented to prepare a PAM-Lignin-CS-Laponite-SA hydrogel for wound dressing. The obtained hydrogel displayed excellent self-healing ability and repeatable adhesive performance, benefiting from the introduction of hydrogen bonding and electrostatic interactions inside the hydrogel network. In addition, the PAM-Lignin-CS-Laponite-SA hydrogel also exhibited low cell cytotoxicity, good antibacterial activity, and outstanding hemostatic properties. In conclusion, the PAM-Lignin-CS-Laponite-SA hydrogel demonstrated good tissue adhesion, excellent self-healing ability, effective bleeding control, and good antibacterial activity to prevent wound infection, which provides a new idea for developing a multifunctional hydrogel-based tissue adhesive hemostatic dressing.

更新日期：2022-11-17

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