A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections,Advanced Materials

当前位置： X-MOL 学术 › Adv. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections
Advanced Materials ( IF 27.4 ) Pub Date : 2022-11-17 , DOI: 10.1002/adma.202208069
Fan Zhao _{1,

2} , Yajuan Su _{1,

2} , Junying Wang _{1,

2} , Svetlana Romanova ₃ , Dominick J DiMaio ₄ , Jingwei Xie _{1,

2} , Siwei Zhao _{1,

2}

Affiliation

Biofilm infection has a high prevalence in chronic wounds and can delay wound healing. Current treatment using debridement and antibiotic administration imposes a significant burden on patients and healthcare systems. To address their limitations, a highly efficacious electrical antibiofilm treatment system is described in this paper. This system uses high-intensity current (75 mA cm⁻²) to completely debride biofilm above the wound surface and enhance antibiotic delivery into biofilm-infected wounds simultaneously. Combining these two effects, this system uses short treatments (≤2 h) to reduce bacterial count of methicillin-resistant S. aureus (MRSA) biofilm-infected ex vivo skin wounds from 10¹⁰ to 10^5.2 colony-forming units (CFU) g⁻¹. Taking advantage of the hydrogel ionic circuit design, this system enhances the in vivo safety of high-intensity current application compared to conventional devices. The in vivo antibiofilm efficacy of the system is tested using a diabetic mouse-based wound infection model. MRSA biofilm bacterial count decreases from 10^9.0 to 10^4.6 CFU g⁻¹ at 1 day post-treatment and to 10^3.3 CFU g⁻¹ at 7 days post-treatment, both of which are below the clinical threshold for infection. Overall, this novel technology provides a quick, safe, yet highly efficacious treatment to chronic wound biofilm infections.

中文翻译：

用于对抗慢性伤口细菌感染的高效电生物膜治疗系统

生物膜感染在慢性伤口中发病率很高，并且会延迟伤口愈合。目前使用清创和抗生素给药的治疗给患者和医疗保健系统带来了沉重的负担。为了解决它们的局限性，本文描述了一种高效的电抗生物膜处理系统。该系统使用高强度电流（75 mA cm ^-2 ）来完全清除伤口表面上方的生物膜，同时增强抗生素向生物膜感染伤口的输送。结合这两种效果，该系统使用短期治疗（≤2 小时）将耐甲氧西林金黄色葡萄球菌(MRSA) 生物膜感染的离体皮肤伤口的细菌计数从 10 ¹⁰菌落形成单位 (CFU) g 减少到 10 ^5.2菌落形成单位 (CFU) g ⁻¹ 。与传统装置相比，该系统利用水凝胶离子电路设计，增强了高强度电流应用的体内安全性。使用基于糖尿病小鼠的伤口感染模型测试该系统的体内抗生物膜功效。 MRSA生物膜细菌计数在治疗后1天从10 ^9.0减少至10 ^4.6 CFU g ^-1 ，并在治疗后7天减少至10 ^3.3 CFU g ^-1 ，两者均低于感染的临床阈值。总体而言，这项新技术为慢性伤口生物膜感染提供了一种快速、安全且高效的治疗方法。

更新日期：2022-11-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南