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Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-11-16 , DOI: 10.1021/acsami.2c15686 Zhipeng Ni 1 , Haojie Yu 1 , Li Wang 1 , Yudi Huang 1 , Hui Lu 2 , Haiying Zhou 2 , Qingxian Liu 3
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-11-16 , DOI: 10.1021/acsami.2c15686 Zhipeng Ni 1 , Haojie Yu 1 , Li Wang 1 , Yudi Huang 1 , Hui Lu 2 , Haiying Zhou 2 , Qingxian Liu 3
Affiliation
The high level of reactive oxygen species (ROS) and bacterial infection impede wound healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid (TA) and ROS-responsive phenylborate ester (PBAE), a series of ROS-responsive anti-inflammatory TA-conjugated nanoparticle hydrogels (PPBA-TA-PVA) can be obtained by conveniently mixing TA, phenylboric acid modified polyphosphazene (PPBA), and poly(vinyl alcohol) (PVA). The obtained PPBA-TA-PVA hydrogels could effectively inhibit the growth of Escherichia coli (antibacterial rate = 93.1 ± 1.1%) within 4 h and effectively scavenge both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and •OH radicals in vitro. Besides, the cell migration rate of HDFa cells treated with PPBA-TA-PVA hydrogels (84.2 ± 4.6%) was twice the rate of normal cells (43.8 ± 8.1%) after 24 h of cocultivation. The clinical relevance was demonstrated further by assessing the PPBA-TA-PVA hydrogels in full-thickness excisional wounds in a streptozotocin (STZ)-induced diabetic rat model. The PPBA-TA-PVA hydrogels could act as effective ROS-scavenging agents to alleviate inflammation and accelerate wound closure by decreasing the proinflammatory cytokines (IL-6, IL-1β) and increasing the gene expression of TGF-β1, COL-1, and COL-3, which resulted in faster re-epithelialization and increased formation of granulation tissue.
中文翻译:
用于糖尿病伤口愈合的多阶段 ROS 响应和天然多酚驱动的前药水凝胶
高水平的活性氧 (ROS) 和细菌感染会阻碍糖尿病伤口的伤口愈合。在这里,受益于单宁酸 (TA) 和 ROS 响应苯硼酸酯 (PBAE) 的抗氧化作用,一系列 ROS 响应抗炎 TA 共轭纳米粒子水凝胶 (PPBA-TA-PVA) 可以通过方便地混合获得TA、苯硼酸改性聚磷腈 (PPBA) 和聚(乙烯醇)(PVA)。获得的PPBA-TA-PVA水凝胶可在4小时内有效抑制大肠杆菌的生长(抗菌率=93.1±1.1%),并有效清除大肠杆菌中的2,2-二苯基-1-苦基肼(DPPH)自由基和•OH自由基。体外. 此外,共培养24小时后,用PPBA-TA-PVA水凝胶处理的HDFa细胞的细胞迁移率(84.2±4.6%)是正常细胞(43.8±8.1%)的两倍。通过在链脲佐菌素 (STZ) 诱导的糖尿病大鼠模型中评估全层切除伤口中的 PPBA-TA-PVA 水凝胶,进一步证明了临床相关性。PPBA-TA-PVA 水凝胶可作为有效的 ROS 清除剂,通过减少促炎细胞因子(IL-6、IL-1β)和增加 TGF-β1、COL-1、和 COL-3,这导致更快的再上皮化和增加肉芽组织的形成。
更新日期:2022-11-16
中文翻译:
用于糖尿病伤口愈合的多阶段 ROS 响应和天然多酚驱动的前药水凝胶
高水平的活性氧 (ROS) 和细菌感染会阻碍糖尿病伤口的伤口愈合。在这里,受益于单宁酸 (TA) 和 ROS 响应苯硼酸酯 (PBAE) 的抗氧化作用,一系列 ROS 响应抗炎 TA 共轭纳米粒子水凝胶 (PPBA-TA-PVA) 可以通过方便地混合获得TA、苯硼酸改性聚磷腈 (PPBA) 和聚(乙烯醇)(PVA)。获得的PPBA-TA-PVA水凝胶可在4小时内有效抑制大肠杆菌的生长(抗菌率=93.1±1.1%),并有效清除大肠杆菌中的2,2-二苯基-1-苦基肼(DPPH)自由基和•OH自由基。体外. 此外,共培养24小时后,用PPBA-TA-PVA水凝胶处理的HDFa细胞的细胞迁移率(84.2±4.6%)是正常细胞(43.8±8.1%)的两倍。通过在链脲佐菌素 (STZ) 诱导的糖尿病大鼠模型中评估全层切除伤口中的 PPBA-TA-PVA 水凝胶,进一步证明了临床相关性。PPBA-TA-PVA 水凝胶可作为有效的 ROS 清除剂,通过减少促炎细胞因子(IL-6、IL-1β)和增加 TGF-β1、COL-1、和 COL-3,这导致更快的再上皮化和增加肉芽组织的形成。