Spatial characterization of redox processes and speciation of Ru(III) anticancer complexes by 19F magnetic resonance imaging,Chemical Communications

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Spatial characterization of redox processes and speciation of Ru(III) anticancer complexes by 19F magnetic resonance imaging
Chemical Communications ( IF 4.3 ) Pub Date : 2022-11-15 , DOI: 10.1039/d2cc04830b
Gregory A MacNeil ₁ , Stephanie W Chang ₁ , Kathleen E Prosser ₁ , Eric Ye ₁ , Devon Heroux ₂ , Andrew R Lewis _{1,

3} , Marcel Bally ₂ , Charles J Walsby ₁

Affiliation

The application of CF₃-labeled Ru(III) anticancer complexes to magnetic resonance (MR) imaging of tumour tissues is demonstrated. By combining anatomical chemical-shift selective (CHESS) imaging with ¹⁹F chemical-shift imaging (CSI) MR methods, we show that oxidation states and ligand-exchange processes of the complexes can be spatially encoded. Measurements on different tissue models, including a human breast adenocarcinoma tumour, validate the application of these complexes as MR theranostics for the sensing and targeting of hypoxia.

中文翻译：

通过 19F 磁共振成像对 Ru(III) 抗癌复合物的氧化还原过程和形态的空间表征

展示了 CF ₃标记的 Ru( III ) 抗癌复合物在肿瘤组织磁共振 (MR) 成像中的应用。通过将解剖化学位移选择性 (CHESS) 成像与¹⁹ F 化学位移成像 (CSI) MR 方法相结合，我们表明可以对复合物的氧化态和配体交换过程进行空间编码。对不同组织模型（包括人类乳腺癌肿瘤）的测量验证了这些复合物作为 MR 治疗诊断学在缺氧感测和靶向方面的应用。

更新日期：2022-11-15

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