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Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study
Scientific Reports ( IF 3.8 ) Pub Date : 2022-11-15 , DOI: 10.1038/s41598-022-24258-7
Qijie Kuang 1 , Sumiao Zhou 1 , Haijing Li 1 , Lin Mi 1 , Yingjun Zheng 1 , Shenglin She 1
Affiliation  

It was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and FER ability in FSZ patients. A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Partial correlation analysis showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = − 0.60, p = 0.004). Our study indicated that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER deficiency in schizophrenia.



中文翻译:


首发精神分裂症患者低频波动分数振幅 (fALFF) 与面部情绪识别能力之间的关联:一项功能磁共振成像研究



首发精神分裂症(FSZ)患者大脑区域静息态内在活动与面部情绪识别(FER)能力之间的相关性尚不清楚。我们的目的是分析 FSZ 患者低频波动分数幅度 (fALFF) 与 FER 能力之间的相关性。共有 28 名 FSZ 患者和 33 名健康对照 (HC) 完成了 FER 能力的视觉搜索任务。与面部情绪相关的感兴趣区域(ROI)是从之前的荟萃分析中获得的。进行 Pearson 相关分析以了解 fALFF 与 FER 能力之间的相关性。我们的结果表明,患者在快乐 FER 和恐惧 FER 的准确度表现上比 HC 差。之前的荟萃分析结果显示,与FER相关的大脑区域包括双侧杏仁核(AMY)/海马体(HIP)、右侧梭状回(FFG)和右侧辅助运动区(SMA)。偏相关分析表明,右侧 FFG 的 fALFF 与高负载可怕的 FER 准确性相关(r = − 0.60, p = 0.004)。我们的研究表明FER能力与面部情绪相关脑区静息态内在活动相关,这可能为精神分裂症FER缺乏的研究提供参考。

更新日期:2022-11-15
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