香草酸的心脏保护潜力,Clinical and Experimental Pharmacology and Physiology

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香草酸的心脏保护潜力
Clinical and Experimental Pharmacology and Physiology ( IF 2.4 ) Pub Date : 2022-11-12 , DOI: 10.1111/1440-1681.13736
Banafsheh Yalameha ₁ , Hamid Reza Nejabati ₂ , Mohammad Nouri ₃

Affiliation

如今，心血管疾病 (CVD) 是对公共卫生的全球威胁，几乎占全世界所有死亡人数的三分之一。氧化应激 (OS) 是促进 CVD 发展的关键机制途径之一，包括心脏毒性 (CTX) 和心肌缺血再灌注损伤 (MIRI)。活性氧 (ROS) 生成的增加与抗氧化能力下降和线粒体功能障碍密切相关。目前，尽管有现代药物可供使用，但膳食来源的抗氧化剂在发达国家中越来越受欢迎，以延缓心血管疾病的进展。从草药、水果、全谷物、果汁、啤酒和葡萄酒中提取的一种抗氧化剂是香草酸 (VA)，作为一种酚类化合物，它具有不同的治疗特性，包括心脏保护作用。根据实验证据，VA 通过减少 ROS 产生来改善线粒体功能，加重抗氧化状态，清除自由基，并降低脂质过氧化水平，从而减少心脏功能障碍，特别是 CTX 和 MIRI。考虑到 OS 在 CVD 病理生理学中的作用，本研究的目的是全面解决关于 VA 在心血管系统中抗氧化重要性的最新证据。

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Cardioprotective potential of vanillic acid

Nowadays, cardiovascular diseases (CVDs) are a global threat to public health, accounting for almost one-third of all deaths worldwide. One of the key mechanistic pathways contributing to the development of CVDs, including cardiotoxicity (CTX) and myocardial ischaemia–reperfusion injury (MIRI) is oxidative stress (OS). Increased generation of reactive oxygen species (ROS) is closely associated with decreased antioxidant capacity and mitochondrial dysfunction. Currently, despite the availability of modern pharmaceuticals, dietary-derived antioxidants are becoming more popular in developed societies to delay the progression of CVDs. One of the antioxidants derived from herbs, fruits, whole grains, juices, beers, and wines is vanillic acid (VA), which, as a phenolic compound, possesses different therapeutic properties, including cardioprotective. Based on experimental evidence, VA improves mitochondrial function as a result of the reduction in ROS production, aggravates antioxidative status, scavenges free radicals, and reduces levels of lipid peroxidation, thereby decreasing cardiac dysfunction, in particular CTX and MIRI. Considering the role of OS in the pathophysiology of CVDs, the purpose of this study is to comprehensively address recent evidence on the antioxidant importance of VA in the cardiovascular system.

更新日期：2022-11-12

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