Enabling Photo-Crosslinking and Photo-Sensitizing Properties for Synthetic Fluorescent Protein Chromophores,Angewandte Chemie International Edition

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Enabling Photo-Crosslinking and Photo-Sensitizing Properties for Synthetic Fluorescent Protein Chromophores
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-12 , DOI: 10.1002/anie.202215215
Huan Feng _{1,

2} , Qun Zhao ₁ , Beirong Zhang _{1,

2} , Hang Hu ₃ , Meng Liu _{2,

4} , Kaifeng Wu ₄ , Xiaosong Li ₃ , Xin Zhang ₅ , Lihua Zhang ₁ , Yu Liu ₁

Affiliation

This work discovered that fluorescence protein chromophore analogs can undergo triplet excitation, enabling photo-crosslinking and photo-sensitizing chemistries. Exploration of these synthetic fluorescent protein chromophores resulted in photo-crosslinkers for biomolecules, photo-catalysts for organic reactions, and photosensitizers for chromophore-assisted light inactivation and photodynamic therapies.

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