Scientific Reports ( IF 3.8 ) Pub Date : 2022-11-10 , DOI: 10.1038/s41598-022-23873-8 Fu-An Yang , Shih-Ching Chen , Jing-Fang Chiu , Ya-Chu Shih , Tsan-Hon Liou , Reuben Escorpizo , Hung-Chou Chen
Different body weight-supported gait-training strategies are available for improving ambulation in individuals with spinal cord injury (SCI). These include body weight-supported overground training (BWSOGT), body weight-supported treadmill training (BWSTT), and robot-assisted gait training (RAGT). We conducted a network meta-analysis of randomised controlled trials (RCTs) to assess the effect and priority of each training protocol. We searched the PubMed, Cochrane Library, Scopus, and Embase databases from inception to 6 August 2022. The eligibility criteria were as follows: (1) being RCTs, (2) recruiting participants with SCI diagnosis and requiring gait training, (3) comparing different body weight-supported gait training strategies, and (4) involving ambulatory assessments. We conducted a network meta-analysis to compare different training strategies using the standard mean difference and its 95% credible interval. To rank the efficacy of training strategies, we used the P score as an indicator. Inconsistency in network meta-analysis was evaluated using loop-specific heterogeneity. We included 15 RCTs in this analysis. RAGT was had significantly more favourable performance than had the control intervention. The ranking probabilities indicated that the most effective approach was RAGT, followed by BWSOGT, BWSTT, and the control intervention. No significant inconsistency was noted between the results of the direct and indirect comparisons.
中文翻译:
脊髓损伤患者的体重支持步态训练:随机对照试验的网络荟萃分析
不同的体重支持步态训练策略可用于改善脊髓损伤 (SCI) 患者的行走能力。这些包括体重支持的地面训练 (BWSOGT)、体重支持的跑步机训练 (BWSTT) 和机器人辅助步态训练 (RAGT)。我们对随机对照试验 (RCT) 进行了网络荟萃分析,以评估每种训练方案的效果和优先级。我们搜索了 PubMed、Cochrane Library、Scopus 和 Embase 数据库,从开始到 2022 年 8 月 6 日。资格标准如下:(1) 是随机对照试验,(2) 招募患有 SCI 诊断并需要步态训练的参与者,(3) 比较不同的体重支持步态训练策略,以及 (4) 涉及动态评估。我们进行了网络荟萃分析,使用标准均值差及其 95% 可信区间比较不同的训练策略。为了对训练策略的功效进行排名,我们使用 P 分数作为指标。使用循环特定异质性评估网络荟萃分析中的不一致性。我们在该分析中纳入了 15 项随机对照试验。RAGT 的表现明显优于对照干预。排序概率表明最有效的方法是 RAGT,其次是 BWSOGT、BWSTT 和控制干预。直接和间接比较的结果之间没有发现明显的不一致。使用循环特定异质性评估网络荟萃分析中的不一致性。我们在该分析中纳入了 15 项随机对照试验。RAGT 的表现明显优于对照干预。排序概率表明最有效的方法是 RAGT,其次是 BWSOGT、BWSTT 和控制干预。直接和间接比较的结果之间没有发现明显的不一致。使用循环特定异质性评估网络荟萃分析中的不一致性。我们在该分析中纳入了 15 项随机对照试验。RAGT 的表现明显优于对照干预。排序概率表明最有效的方法是 RAGT,其次是 BWSOGT、BWSTT 和控制干预。直接和间接比较的结果之间没有发现明显的不一致。