Glaucoma is one of the irreversible ocular diseases that can cause vision loss in some serious cases. Although Triggerfish has been commercialized for monitoring intraocular pressure in glaucoma, there is no smart contact lens to monitor intraocular pressure and take appropriate drug treatment in response to the intraocular pressure levels. Here, we report a precisely integrated theranostic smart contact lens with a sensitive gold hollow nanowire based intraocular pressure sensor, a flexible drug delivery system, wireless power and communication systems and an application specific integrated circuit chip for both monitoring and control of intraocular pressure in glaucoma. The gold hollow nanowire based intraocular pressure sensor shows high ocular strain sensitivity, chemical stability and biocompatibility. Furthermore, the flexible drug delivery system can be used for on-demand delivery of timolol for intraocular pressure control. Taken together, the intraocular pressure levels can be successfully monitored and controlled by the theranostic smart contact lens in glaucoma induced rabbits. This theranostic smart contact lens would be harnessed as a futuristic personal healthcare platform for glaucoma and other ocular diseases.

青光眼是不可逆的眼部疾病之一，在某些严重的情况下会导致视力丧失。尽管Triggerfish已经商业化用于监测青光眼眼压，但目前还没有智能隐形眼镜可以监测眼压并根据眼压水平采取适当的药物治疗。在这里，我们报告了一种精确集成的治疗诊断智能隐形眼镜，带有基于敏感金空心纳米线的眼压传感器、灵活的药物输送系统、无线电力和通信系统以及用于监测和控制青光眼眼压的专用集成电路芯片。基于金空心纳米线的眼压传感器表现出高眼应变敏感性、化学稳定性和生物相容性。此外，灵活的药物输送系统可用于按需输送噻吗洛尔以控制眼压。综上所述，治疗诊断智能隐形眼镜可以成功监测和控制青光眼诱发兔的眼压水平。这种治疗诊断智能隐形眼镜将被用作治疗青光眼和其他眼部疾病的未来个人医疗保健平台。