Pharmaceuticals and personal care products (PPCPs) are commonly seen emerging organic contaminants in aquatic environments. The transects for the occurrence and distribution of 24 PPCPs along the middle and lower reaches of the Yellow River (Henan section) were investigated in this study. All 24 targeted compounds were detected in surface water, with concentrations in the range from not detected (ND) to 527.4 ng/L. Among these PPCPs, caffeine is found to have the highest concentration and its detection frequency is 100%. The total PPCP concentration ranged from 136 ng/L to 916 ng/L (median, 319.5 ng/L). Spatial analysis showed that the pollution level of PPCPs in the trunk stream was lower than that in most tributaries in the middle and lower reaches of the Yellow River (Henan section). The ecotoxicological risk assessment indicated that norfloxacin, azithromycin, estrone, and triclosan posed high risks to aquatic organisms (RQ > 1), roxithromycin and oxytetracycline imposed moderate risks (0.1 ≤ RQ < 1), and the tributary Jindi River had the highest mixed risk (MRQ = 222).

药物和个人护理产品 (PPCP) 是水生环境中常见的新兴有机污染物。调查了黄河中下游（河南段）24个PPCPs的产状和分布断面。在地表水中检测到所有 24 种目标化合物，浓度范围从未检测到 (ND) 到 527.4 ng/L。在这些 PPCP 中，咖啡因的浓度最高，检测频率为 100%。PPCP 总浓度范围为 136 ng/L 至 916 ng/L（中值，319.5 ng/L）。空间分析表明，黄河中下游（河南段）干流PPCPs污染水平低于大部分支流。