A novel ligand, 2-(1, 3-benzothiazol-2-ylamino)-N-(5-chloro-2-hydroxyphenyl)acetamide (BCA) and its Co(II), Ni(II), Cu(II) complexes have been synthesised. The ligand and their complexes have been characterised by ¹H,¹³C, NMR, IR, UV–Visible, mass spectra, TGA and P-XRD studies. The spectral data indicate that the ligand is tridentate and produce distorted octahedral geometry around the metal ion. The electrocatalytic ability of [Co(BCA)₂]Cl₂/GCE (modified electrode) under different concentrations of glucose and H₂O₂ were verified with cyclic voltammetry studies (CV). The modified electrode worked as a good sensor with glucose and H₂O₂ at the concentration 0.4 to 2 µML⁻¹ and 0.2 to 0.8 µML⁻¹ with limit of detection (LOD) of 0.133 µM and 0.0666 µM respectively. This electrode exhibit the sensitivity of 1.89 and 2.8784 µAµM⁻¹ cm⁻² for glucose and H₂O₂ respectively. Thus, the modified electrode performed better, had a longer shelf life and produced more reduplication and procreation. The established procedure was used to examine the bio efficiency of the synthesised ligand and its metal-coordinated compounds against bacteria and fungi. In addition, BCA and its metal compounds were tested for antioxidant and cytotoxic effects on three different cell strains (P53, HeLa and Hep-G2). The Co(II) and Cu (II) complexes exhibited excellent cytotoxicity for P53 and HeLa cell lines. Further, the molecular docking studies on cancer receptors were done to investigate the binding efficiency of metal complexes.

一种新型配体，2-(1, 3-benzothiazol-2-ylamino) -N- (5-chloro-2-hydroxyphenyl)acetamide (BCA) 及其 Co(II)、Ni(II)、Cu(II) 配合物已经合成。^已通过1 H、¹³ C、NMR、IR、UV-Visible、质谱、TGA 和 P-XRD 研究对配体及其配合物进行了表征。光谱数据表明配体是三齿的，并在金属离子周围产生扭曲的八面体几何形状。通过循环伏安研究（CV）验证了[Co(BCA) ₂ ]Cl ₂ /GCE（修饰电极）在不同浓度葡萄糖和H ₂ O _{2下的电催化能力。}修饰电极可用作葡萄糖和 H _{2的良好传感器}O ₂浓度为 0.4 到 2 µML ^-1和 0.2 到 0.8 µML ^-1，检测限 (LOD) 分别为 0.133 µM 和 0.0666 µM。该电极对葡萄糖和 H ₂ O ₂的灵敏度分别为 1.89 和 2.8784 µAµM ^-1 cm ^-2分别。因此，修饰电极性能更好，保质期更长，并产生更多的复制和繁殖。已建立的程序用于检查合成的配体及其金属配位化合物对细菌和真菌的生物效率。此外，还测试了 BCA 及其金属化合物对三种不同细胞株（P53、HeLa 和 Hep-G2）的抗氧化和细胞毒性作用。Co(II) 和 Cu (II) 配合物对 P53 和 HeLa 细胞系表现出优异的细胞毒性。此外，还对癌症受体进行了分子对接研究，以研究金属配合物的结合效率。