用于加速糖尿病伤口愈合的基于微藻的生物混合微型机器人,Small

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用于加速糖尿病伤口愈合的基于微藻的生物混合微型机器人
Small ( IF 13.0 ) Pub Date : 2022-11-10 , DOI: 10.1002/smll.202204617
Hyunsik Choi _{1,

2} , Bolam Kim ₃ , Sang Hoon Jeong ₄ , Tae Yeon Kim ₄ , Dong-Pyo Kim ₅ , You-Kwan Oh ₃ , Sei Kwang Hahn _{2,

4}

Affiliation

已经提出了多种伤口愈合平台来减轻缺氧条件和/或调节用于治疗糖尿病慢性伤口的免疫反应。然而，这些治疗剂通过血凝块被动扩散的平台导致进入深部伤口部位的递送效率相对较低。在这里，开发了一种用于加速糖尿病伤口愈合的基于微藻的生物混合微型机器人。^{生物混合微型机器人以 33.3 µm s -1}的速度自主移动并产生氧气以缓解缺氧状态。此外，微型机器人可有效结合白细胞介素 8 (IL-8) 和单核细胞趋化蛋白 1 (MCP-1) 的炎症趋化因子，以调节免疫反应。通过使用微流体设备测量仿生伤口中的纤维蛋白凝块，证实了微型机器人的增强渗透，并且在真实受伤的小鼠皮肤组织中证实了微型机器人的增强保留。糖尿病小鼠慢性创面未敷料沉积后，微机器人治疗创面9天后完全愈合，炎性细胞因子显着下降低于对照水平31%，血管生成上调CD31 ^{+ 20倍以上}细胞。这些结果证实了微型机器人作为下一代糖尿病伤口愈合平台的可行性。

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Microalgae-Based Biohybrid Microrobot for Accelerated Diabetic Wound Healing

A variety of wound healing platforms have been proposed to alleviate the hypoxic condition and/or to modulate the immune responses for the treatment of chronic wounds in diabetes. However, these platforms with the passive diffusion of therapeutic agents through the blood clot result in the relatively low delivery efficiency into the deep wound site. Here, a microalgae-based biohybrid microrobot for accelerated diabetic wound healing is developed. The biohybrid microrobot autonomously moves at velocity of 33.3 µm s⁻¹ and generates oxygen for the alleviation of hypoxic condition. In addition, the microrobot efficiently bound with inflammatory chemokines of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) for modulating the immune responses. The enhanced penetration of microrobot is corroborated by measuring fibrin clots in biomimetic wound using microfluidic devices and the enhanced retention of microrobot is confirmed in the real wounded mouse skin tissue. After deposition on the chronic wound in diabetic mice without wound dressing, the wounds treated with microrobots are completely healed after 9 days with the significant decrease of inflammatory cytokines below 31% of the control level and the upregulated angiogenesis above 20 times of CD31⁺ cells. These results confirm the feasibility of microrobots as a next-generation platform for diabetic wound healing.

更新日期：2022-11-10

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