Lactate-Oxidase-Instructed Cancer Diagnosis and Therapy,Advanced Materials

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Lactate-Oxidase-Instructed Cancer Diagnosis and Therapy
Advanced Materials ( IF 27.4 ) Pub Date : 2022-11-10 , DOI: 10.1002/adma.202207951
Shanshan Jiang ₁ , Xin Chen ₁ , Jing Lin ₁ , Peng Huang ₁

Affiliation

Lactate oxidase (LOx) has attracted extensive interest in cancer diagnosis and therapy in recent years owing to its specific catalysis on l-lactate; its catalytic process consumes oxygen (O₂) and generates a large amount of hydrogen peroxide (H₂O₂) and pyruvate. Given high levels of lactate in tumor tissues and its tight correlation with tumor growth, metastasis, and recurrence, LOx-based biosensors including H₂O₂-based, O₂-based, pH-sensitive, and electrochemical have been designed for cancer diagnosis, and various LOx-based cancer therapy strategies including lactate-depletion-based metabolic cancer therapy/immunotherapy, hypoxia-activated chemotherapy, H₂O₂-based chemodynamic therapy, and multimodal synergistic cancer therapy have also been developed. In this review, the lactate-specific catalytic properties of LOx are introduced, and the recent advances on LOx-instructed cancer diagnostic or therapeutic platforms and corresponding biological applications are summarized. Additionally, the challenges and potential of LOx-based nanomedicines are highlighted.

中文翻译：

乳酸氧化酶指导的癌症诊断和治疗

乳酸氧化酶 (LOx) 由于其对l-乳酸的特异性催化作用，近年来在癌症诊断和治疗中引起了广泛关注；其催化过程消耗氧气（O ₂）并产生大量的过氧化氢（H ₂ O ₂）和丙酮酸盐。鉴于肿瘤组织中的高水平乳酸及其与肿瘤生长、转移和复发的紧密相关性，基于 LOx 的生物传感器（包括基于 H 2 _O 2_的、基于 O ₂的、pH 敏感的和电化学的）已被设计用于癌症诊断，以及各种基于 LOx 的癌症治疗策略，包括基于乳酸耗竭的代谢性癌症治疗/免疫治疗、缺氧激活化疗、H_{还开发了基于2} O ₂的化学动力学疗法和多模式协同癌症疗法。在这篇综述中，介绍了 LOx 的乳酸特异性催化特性，并总结了 LOx 指导的癌症诊断或治疗平台和相应生物学应用的最新进展。此外，还强调了基于 LOx 的纳米药物的挑战和潜力。

更新日期：2022-11-10

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