Multifunctional Dual Cross-Linked Bioadhesive Patch with Low Immunogenic Response and Wet Tissues Adhesion,Advanced Healthcare Materials

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Multifunctional Dual Cross-Linked Bioadhesive Patch with Low Immunogenic Response and Wet Tissues Adhesion
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-11-10 , DOI: 10.1002/adhm.202201578
Yang Tang ₁ , Guidong Gong _{1,

2} , Xianglian He ₁ , Mengyuan Dai ₁ , Mei Chen ₁ , Bo Wang ₃ , Yajie Wang ₄ , Xiaoling Wang _{1,

2} , Junling Guo _{1,

2,

5,

6}

Affiliation

The development of bioadhesives is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, that is, strong adhesion, water resistance, and high biocompatibility. Here, a biocompatible and biodegradable protein-based bioadhesive patch (PBP) with high adhesion strength and low immunogenic response is reported. PBP exists as a strong adhesion for biological surfaces, which is higher than some conventional bioadhesives (i.e., polyethylene glycol and fibrin). Robust adhesion and strength are realized through the removal of interfacial water and fast formation of multiple supramolecular interactions induced by metal ions. The PBP's high biocompatibility is evaluated and immunogenic response in vitro and in vivo is neglected. The strong adhesion on soft biological tissues qualifies the PBP as biomedical glue outperforming some commercial products for applications in hemostasis performance, accelerated wound healing, and sealing of defected organs, anticipating to be useful as a tissue adhesive and sealant.

中文翻译：

具有低免疫原性反应和湿组织粘附的多功能双交联生物粘附贴剂

生物粘合剂的开发是一项重要但具有挑战性的任务，因为需要将看似相互排斥的特性结合在一种材料中，即强粘附性、耐水性和高生物相容性。在这里，报道了一种具有高粘附强度和低免疫原性反应的生物相容性和可生物降解的基于蛋白质的生物粘附贴片 (PBP)。PBP 作为对生物表面的强粘附力存在，比一些常规生物粘附剂（即聚乙二醇和纤维蛋白）更高。通过去除界面水和金属离子诱导的多重超分子相互作用的快速形成，实现了牢固的附着力和强度。评估 PBP 的高生物相容性，忽略体外和体内的免疫原性反应。

更新日期：2022-11-10

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