具有三重酶模拟活性的碳点@MXene 纳米酶用于温和的 NIR-II 光热放大纳米催化疗法,Advanced Healthcare Materials

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具有三重酶模拟活性的碳点@MXene 纳米酶用于温和的 NIR-II 光热放大纳米催化疗法
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-11-10 , DOI: 10.1002/adhm.202202154
Bijiang Geng _{1,

2} , Lang Yan ₁ , Yuping Zhu ₃ , Wenjing Shi ₁ , Haoneng Wang ₁ , Jingjing Mao ₁ , Lijun Ren ₁ , Jiqianzhu Zhang ₁ , Yijun Tian ₁ , Fangyuan Gao ₁ , Xiaofang Zhang ₁ , Jikuai Chen ₁ , Jiangbo Zhu ₁

Affiliation

由于低成本、易于制备和高稳定性等优点，纳米酶在疾病治疗中显示出巨大的潜力。然而，高度复杂的肿瘤微环境（TME）和固有的低催化活性严重限制了纳米酶的临床应用。在此，通过将 N 掺杂碳点 (CD) 沉积到 Nb ₂ C 纳米片上，构建了一种基于 Z 型异质结纳米酶的新型温和热疗增强纳米催化治疗平台。CD@Nb ₂C 纳米酶不仅在安全高效的 NIR-II 窗口中显示出出色的光热效应，而且还具有三重酶模拟活性以获得放大的 ROS 水平。由于加速的载流子转移过程，Z 型异质结的构建增强了 CD 纳米酶的三重酶模拟活性和 NIR-II 光热特性。_{更重要的是，温和热疗的引入可以进一步提高CD@Nb 2} C纳米酶的过氧化物酶模拟和过氧化氢酶模拟活性以及glGSH耗竭能力，从而产生更多的ROS以有效抑制肿瘤生长。_{CD@Nb 2}的联合治疗效果C 纳米酶通过温和的 NIR-II 光热增强纳米催化疗法可以实现完全根除肿瘤。这项工作突出了异质结纳米酶的有效肿瘤治疗潜力。

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Carbon Dot@MXene Nanozymes with Triple Enzyme-Mimic Activities for Mild NIR-II Photothermal-Amplified Nanocatalytic Therapy

Nanozymes have shown promising potential in disease treatment owing to the advantages of low-cost, facile fabrication, and high stability. However, the highly complex tumor microenvironment (TME) and inherent low catalytic activity severely restrict the clinical applications of nanozymes. Herein, a novel mild hyperthermia-enhanced nanocatalytic therapy platform based on Z-scheme heterojunction nanozymes by depositing N-doped carbon dots (CDs) onto Nb₂C nanosheets is constructed. CD@Nb₂C nanozymes not only display outstanding photothermal effects in the safe and efficient NIR-II window but also possess triple enzyme-mimic activities to obtain amplified ROS levels. The triple enzyme-mimic activities and NIR-II photothermal properties of CD nanozymes are enhanced by the construction of Z-scheme heterojunctions owing to the accelerated carrier transfer process. More importantly, the introduction of mild hyperthermia can further improve the peroxidase-mimic and catalase-mimic activities as well as the glGSH depletion abilities of CD@Nb₂C nanozymes, thereby producing more ROS to efficiently inhibit tumor growth. The combined therapy effect of CD@Nb₂C nanozymes through mild NIR-II photothermal-enhanced nanocatalytic therapy can achieve complete tumor eradication. This work highlights the efficient tumor therapy potential of heterojunction nanozymes.

更新日期：2022-11-10

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