The present study is designed to illuminate the dynamics of the Jamuna River in Bangladesh for 46 years, from 1973 to 2019. About 240 km of the Jamuna River course was assessed using remote sensing and GIS. Landsat remote sensing imageries were processed, and bank lines were extracted and analysed using GIS. The main objective of the study was to understand the pattern of bed movement of the Jamuna River. The river dynamics were assessed based on bank erosion, accretion, bank line shifts, channel width, and river course and confluence shift. Area vulnerable to erosion was assessed using historical erosion rate and trend analysis. The result revealed that the river area increased by about 48% over 46 years. The total eroded area was about 1038 km², with 35.40% more erosion on the left bank than on the right. Due to higher erosion than deposition, the river widened. The average width of the river increased by about 56.40% during the period. The average rate of shifting was higher on the left bank than on the right, indicating the eastward movement of the river. Impact analysis showed that overall, a total of 822 km² and 390 km² of croplands and settlements were eroded during the period 1973–2019. The width of the confluence at the Padma River junction decreased by about 28%. The straight shift of the confluence was 9.27 km towards the southeast. The vulnerable area assessment anticipated that there would be more erosion on the left bank than on the right, and that Kurigram, Tangail and Jamalpur are the districts most susceptible to future left bank erosion. And, the lower reach of the right bank of the Padma River is at high vulnerable to erosion at the confluence. The methods and analysis adopted in this study can be applied to any other braided river to monitor the dynamics of the river and to formulate an action plan to protect the river from erosion.