Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates,Russian Journal of General Chemistry

当前位置： X-MOL 学术 › Russ. J. Gen. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2022-11-08 , DOI: 10.1134/s1070363222100048
I. A. Gorbunova , Yu. O. Sharavyeva , R. R. Makhmudov , D. A. Shipilovskikh , V. M. Shadrin , N. A. Pulina , S. A. Shipilovskikh

Abstract

A method was proposed for the synthesis of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates containing a nitrile substituent in the thiophene ring by reacting the corresponding 3-thienylimino-3H-furan-2-ones with primary alcohols. The antinociceptive activity and acute toxicity of the obtained compounds were investigated. It was found that the substituted esters have pronounced antinociceptive activity and low toxicity. According to the classification of toxicity of drugs, the obtained substituted of 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates belong to the V class toxicity.

更新日期：2022-11-10

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南