Conjugated/nonconjugated alternating copolymers for enhanced NIR-II fluorescence imaging and NIR-II photothermal-ferrotherapy,Journal of Materials Chemistry B

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Conjugated/nonconjugated alternating copolymers for enhanced NIR-II fluorescence imaging and NIR-II photothermal-ferrotherapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-11-09 , DOI: 10.1039/d2tb01567f
Pengfei Sun ₁ , Zelan Yang ₁ , Fan Qu ₁ , Xinlong Du ₁ , Qingming Shen ₁ , Quli Fan ₁

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Conjugated polymers hold great promise for NIR-II fluorescence imaging (FI)-guided NIR-II photothermal therapy (PTT) due to the advantages of easy modification of chemical structures and adjustable NIR absorption. However, to make use of these advantages, it is of paramount importance to formulate conjugated polymers with excellent solubility in organic solution, great NIR-II photothermal conversion efficiency, and high NIR-II fluorescence quantum yield. Herein, a new class of conjugated/nonconjugated alternating copolymers (CNACPs) is reported by introducing nonconjugated linkers into a conjugated backbone to modulate the extinction coefficient at 1064 nm and NIR-II fluorescence quantum yield. The NIR-II absorption, NIR-II emission, and NIR-II photothermal properties of the new CNACPs were studied. Interestingly, it is observed that longer nonconjugated linkers in CNACPs result in higher NIR-II fluorescence intensity with sufficient NIR-II absorption and NIR-II photothermal ability. With these newly developed CNACPs (BBT-C6), phototheranostic nanoparticles (BBTD6/Fe@PMA) are prepared through facile nanoprecipitation using PMA-AD-PEG as an iron ion chelator for NIR-II FI-guided NIR-II PTT/ferrotherapy synergistic therapy. In vitro and in vivo, BBTD6/Fe@PMA effectively inhibited 4T1 cells and tumor progression under 1064 nm laser irradiation. Consequently, this work provides new CNACPs by incorporating nonconjugated linkers into a conjugated backbone to design more effective NIR-II fluorescence imaging and NIR-II photothermal therapy agents.

中文翻译：

用于增强 NIR-II 荧光成像和 NIR-II 光热铁疗法的共轭/非共轭交替共聚物

由于化学结构易于修饰和 NIR 吸收可调的优点，共轭聚合物在 NIR-II 荧光成像 (FI) 引导的 NIR-II 光热疗法 (PTT) 方面具有广阔前景。然而，为了利用这些优势，配制在有机溶液中具有优异溶解性、高 NIR-II 光热转换效率和高 NIR-II 荧光量子产率的共轭聚合物至关重要。在此，通过将非共轭接头引入共轭主链来调节 1064 nm 的消光系数和 NIR-II 荧光量子产率，报道了一类新的共轭/非共轭交替共聚物 (CNACPs)。研究了新型 CNACPs 的 NIR-II 吸收、NIR-II 发射和 NIR-II 光热特性。有趣的是，据观察，CNACPs 中较长的非共轭接头导致较高的 NIR-II 荧光强度，具有足够的 NIR-II 吸收和 NIR-II 光热能力。使用这些新开发的 CNACPs (BBT-C6)，使用 PMA-AD-PEG 作为铁离子螯合剂，通过简单的纳米沉淀制备光疗纳米颗粒 (BBTD6/Fe@PMA)，用于 NIR-II FI 引导的 NIR-II PTT/铁疗法协同治疗。在体外和体内，BBTD6/Fe@PMA 在 1064 nm 激光照射下有效抑制 4T1 细胞和肿瘤进展。因此，这项工作通过将非共轭接头结合到共轭主链中来提供新的 CNACP，以设计更有效的 NIR-II 荧光成像和 NIR-II 光热治疗剂。

更新日期：2022-11-09

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