In recent years, BODIPY-based theranostics have increasingly been used in cancer therapy and have achieved significant success. According to photochemical theories, the optical imaging (e.g., fluorescence [FLI]/photoacoustic [PAI]/photothermal imaging [PTI]) and phototherapy properties (photodynamic therapy [PDT] and photothermal therapy [PTT]) of BODIPY-based dyes can be well-tuned and balanced by chemical structural modifications. Furthermore, with the benefits of molecular/nanoparticle engineering, BODIPY-based theranostics can be endowed with versatile functionalities, including other cutting-edge therapeutic modalities, commendable tumor-targeting ability, and a delicate balance between imaging and therapy performance in a molecular/nano-entity, further enhancing its synergetic therapeutic potency and minimizing the undesirable side effects. In this review, we focus on BODIPY-based theranostics for tumor therapy and describe and discuss BODIPY-based FLI-guided chemotherapy, FLI-guided PDT, FLI-guided phototherapies, FLI-guided multi-modal therapies, and PAI-guided phototherapies, as well as multi-modal imaging-guided multi-modal therapies, particularly those that have become available in the last 3 years. The progress and bottlenecks of recent BODIPY-based theranostics are also itemized and discussed, describing the general design principles of BODIPY-based theranostics, with the aim of promoting the use of the theranostics in the clinical transformation of cancer therapy.

近年来，基于 BODIPY 的治疗诊断学越来越多地用于癌症治疗并取得了显着的成功。根据光化学理论，光学成像（例如.、荧光 [FLI]/光声 [PAI]/光热成像 [PTI]）和基于 BODIPY 的染料的光疗特性（光动力疗法 [PDT] 和光热疗法 [PTT]）可以通过化学结构修饰得到很好的调整和平衡. 此外，凭借分子/纳米粒子工程的优势，基于 BODIPY 的治疗诊断学可以被赋予多种功能，包括其他尖端治疗方式、值得称道的肿瘤靶向能力，以及分子/纳米成像和治疗性能之间的微妙平衡。 -entity，进一步增强其协同治疗效力并最大限度地减少不良副作用。在这篇综述中，我们专注于基于 BODIPY 的肿瘤治疗治疗学，并描述和讨论基于 BODIPY 的 FLI 引导的化疗、FLI 引导的 PDT、FLI 引导的光疗、FLI 引导的多模式疗法和 PAI 引导的光疗法，以及多模式成像引导的多模式疗法，特别是那些在过去 3 年中可用的疗法。还对近期基于BODIPY的治疗学的进展和瓶颈进行了逐条讨论，描述了基于BODIPY的治疗学的一般设计原则，旨在促进治疗学在癌症治疗临床转化中的应用。