Differences in salivary secretion and epidermal growth factor concentrations in mild reflux esophagitis and non-erosive reflux disease,Esophagus

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Differences in salivary secretion and epidermal growth factor concentrations in mild reflux esophagitis and non-erosive reflux disease
Esophagus ( IF 2.2 ) Pub Date : 2022-11-07 , DOI: 10.1007/s10388-022-00966-x
Mai Koeda ₁ , Eri Momma ₁ , Tomohide Tanabe ₁ , Yuichi Kitasako _{1,

2,

3} , Yoshimasa Hoshikawa ₁ , Shintaro Hoshino ₁ , Noriyuki Kawami ₁ , Katsuhiko Iwakiri ₁

Affiliation

Background

Sex differences in salivary secretion have been reported among healthy subjects. In the present study, salivary secretion and salivary epidermal growth factor (EGF) concentrations were investigated in mild reflux esophagitis patients, non-erosive reflux disease (NERD) patients, and healthy controls by matching the sex ratio.

Methods

Thirty-three (male:female = 11:22) patients with NERD, 33 (11:22) with mild reflux esophagitis, and 33 (11:22) healthy controls were recruited for this case–control study. Salivary secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy, and the amount of saliva secretion, salivary pH, and salivary pH after acid loading as an index of the acid-buffering capacity were measured. Salivary EGF concentrations were measured by ELISA.

Results

No significant differences were observed in the amount of saliva secretion, salivary pH, or the acid-buffering capacity between the mild reflux esophagitis and NERD groups. However, the amount of saliva secretion and the acid-buffering capacity in the mild reflux esophagitis group and the amount of saliva secretion, salivary pH, and the acid-buffering capacity in the NERD group were significantly lower than those in the healthy control group. No significant differences were noted in salivary EGF concentrations between the mild reflux esophagitis and NERD groups.

Conclusion

After matching the sex ratio, the saliva secretion was significantly lower in patients with mild reflux esophagitis and NERD than in healthy controls. However, no significant differences were observed in the amount of saliva secretion or salivary EGF concentrations between both groups.

中文翻译：

轻度反流性食管炎和非糜烂性反流病唾液分泌和表皮生长因子浓度的差异

背景

据报道，健康受试者的唾液分泌存在性别差异。在本研究中，通过匹配性别比例，研究轻度反流性食管炎患者、非糜烂性反流病 (NERD) 患者和健康对照者的唾液分泌和唾液表皮生长因子 (EGF) 浓度。

方法

本病例对照研究招募了 33 名（男：女 = 11:22）NERD 患者、33 名（11:22）轻度反流性食管炎患者和 33 名（11:22）健康对照者。唾液分泌评估如下：每位患者在内窥镜检查前咀嚼无糖口香糖 3 分钟，并测量唾液分泌量、唾液 pH 值和酸负荷后唾液 pH 值作为酸缓冲能力的指标。通过 ELISA 测量唾液 EGF 浓度。