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Merging photoredox with copper catalysis: enantioselective remote cyanation via 1,4-heteroaryl migration
Chemical Communications ( IF 4.3 ) Pub Date : 2022-11-08 , DOI: 10.1039/d2cc04653a Kang Guo 1 , Chunyu Han 1 , Xiaofei Xie 1 , Bin Chen 1 , Shujun Cao 1 , Weidong Yuan 1 , Kang Chen 1 , Fang Liu 1 , Yingguang Zhu 1
Chemical Communications ( IF 4.3 ) Pub Date : 2022-11-08 , DOI: 10.1039/d2cc04653a Kang Guo 1 , Chunyu Han 1 , Xiaofei Xie 1 , Bin Chen 1 , Shujun Cao 1 , Weidong Yuan 1 , Kang Chen 1 , Fang Liu 1 , Yingguang Zhu 1
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We have developed a photoredox/Cu dual catalyzed enantioselective remote cyanation via 1,4-heteroaryl migration. Experimental and computational studies have been carried out to reveal the reaction mechanism and explain the origins of the regio- and enantioselectivities of the remote cyanation process. This methodology exhibits mild conditions, a broad substrate scope and good regio- and enantioselectivities, which provides a unique approach for catalyst-controlled asymmetric backbone recombination of molecules via functional group migration.
中文翻译：
合并光氧化还原与铜催化：通过 1,4-杂芳基迁移实现对映选择性远程氰化
我们通过1,4-杂芳基迁移开发了光氧化还原/Cu 双催化对映选择性远程氰化。已经进行了实验和计算研究以揭示反应机制并解释远程氰化过程的区域选择性和对映选择性的起源。该方法具有温和的条件、广泛的底物范围和良好的区域选择性和对映选择性，为通过官能团迁移进行催化剂控制的分子不对称主链重组提供了独特的方法。
更新日期：2022-11-08
中文翻译：
合并光氧化还原与铜催化：通过 1,4-杂芳基迁移实现对映选择性远程氰化
我们通过1,4-杂芳基迁移开发了光氧化还原/Cu 双催化对映选择性远程氰化。已经进行了实验和计算研究以揭示反应机制并解释远程氰化过程的区域选择性和对映选择性的起源。该方法具有温和的条件、广泛的底物范围和良好的区域选择性和对映选择性，为通过官能团迁移进行催化剂控制的分子不对称主链重组提供了独特的方法。
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